Assay Detail
Functional
CHEMBL2363362
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SANGER: Inhibition of human KYSE-70 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KYSE-70 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.53 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.74 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.21 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.12 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.78 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.42 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.32 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.27 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.16 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.04 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.82 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.65 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.65 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.62 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.52 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.48 |
| CHEMBL585951 | — | — | 1 | 6.20 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.13 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.09 |
| CHEMBL2363137 | — | — | 1 | 6.09 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.86 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.85 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.76 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.73 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.62 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.51 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.51 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 5.50 |
| CHEMBL379975 | — | — | 1 | 5.41 |
| CHEMBL191384 | — | — | 1 | 5.39 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.1805 | nM | 9.74 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 6.244 | nM | 8.21 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 7.581 | nM | 8.12 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 16.69 | nM | 7.78 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 38.12 | nM | 7.42 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 48.35 | nM | 7.32 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 54.05 | nM | 7.27 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 69.45 | nM | 7.16 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 92.14 | nM | 7.04 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 151.79 | nM | 6.82 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 224.66 | nM | 6.65 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 224.31 | nM | 6.65 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 238.45 | nM | 6.62 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 299.69 | nM | 6.52 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 332.83 | nM | 6.48 |
| CHEMBL585951 | — | IC50 | = | 627.23 | nM | 6.20 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 744.77 | nM | 6.13 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 820.41 | nM | 6.09 |
| CHEMBL2363137 | — | IC50 | = | 812.1 | nM | 6.09 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 1378.84 | nM | 5.86 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1408.87 | nM | 5.85 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1744.42 | nM | 5.76 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1857.16 | nM | 5.73 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 2415.66 | nM | 5.62 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 3088.82 | nM | 5.51 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 3111.93 | nM | 5.51 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 3199.93 | nM | 5.50 |
| CHEMBL379975 | — | IC50 | = | 3852.19 | nM | 5.41 |
| CHEMBL191384 | — | IC50 | = | 4062.23 | nM | 5.39 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4293.4 | nM | 5.37 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 5148.59 | nM | 5.29 |
| CHEMBL217354 | — | IC50 | = | 5307.62 | nM | 5.28 |
| CHEMBL258844 | — | IC50 | = | 5651.45 | nM | 5.25 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 6165.83 | nM | 5.21 |
| CHEMBL572881 | MOTESANIB | IC50 | = | 6393.85 | nM | 5.19 |
| CHEMBL135561 | — | IC50 | = | 8049.58 | nM | 5.09 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 8077.29 | nM | 5.09 |
| CHEMBL939 | GEFITINIB | IC50 | = | 8197.61 | nM | 5.09 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 8454.47 | nM | 5.07 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 9880.11 | nM | 5.00 |
| CHEMBL1190711 | — | IC50 | = | 10342.98 | nM | 4.99 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 12104.58 | nM | 4.92 |
| CHEMBL259181 | — | IC50 | = | 14351.71 | nM | 4.84 |
| CHEMBL221137 | EMBELIN | IC50 | = | 15148.8 | nM | 4.82 |
| CHEMBL105442 | CI-1040 | IC50 | = | 17288.96 | nM | 4.76 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 17733.51 | nM | 4.75 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 20805.89 | nM | 4.68 |
| CHEMBL1023 | BEXAROTENE | IC50 | = | 21633.87 | nM | 4.67 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 26531.75 | nM | 4.58 |
| CHEMBL210618 | — | IC50 | = | 27124.95 | nM | 4.57 |