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Assay Detail

CHEMBL2363366

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Functional
SANGER: Inhibition of human LAMA-84 cell growth in a cell viability assay.
ChEMBL ↗
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type LAMA-84
Confidence 1 — Organism
Curated By Autocuration

Target

LAMA-84 (CHEMBL2366090) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 130 5.94 9.78

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1171837 PONATINIB 4.0 1 9.78
CHEMBL325041 BORTEZOMIB 3.0 1 8.46
CHEMBL1201182 TEMSIROLIMUS 4.0 1 8.39
CHEMBL255863 NILOTINIB 4.0 1 8.31
CHEMBL65 CAMPTOTHECIN -1.0 1 8.15
CHEMBL159 VINBLASTINE 4.0 1 8.15
CHEMBL34259 METHOTREXATE 4.0 1 7.91
CHEMBL3545252 DOCETAXEL 4.0 1 7.88
CHEMBL94657 PATUPILONE 3.0 1 7.72
CHEMBL96926 THAPSIGARGIN — 1 7.71
CHEMBL1256459 TORIN1 — 1 7.66
CHEMBL1879463 DACTOLISIB 3.0 1 7.45
CHEMBL514499 GW843682X — 1 7.40
CHEMBL252164 LUMINESPIB 2.0 1 7.38
CHEMBL553025 VINORELBINE 4.0 1 7.34
CHEMBL603469 LESTAURTINIB 3.0 1 7.31
CHEMBL1972860 ELESCLOMOL 3.0 1 7.28
CHEMBL449158 BRYOSTATIN 1 2.0 1 7.23
CHEMBL941 IMATINIB 4.0 1 7.14
CHEMBL507361 MIRDAMETINIB 2.0 1 7.02
CHEMBL888 GEMCITABINE 4.0 1 6.94
CHEMBL428647 PACLITAXEL 4.0 1 6.89
CHEMBL513909 BI-2536 2.0 1 6.88
CHEMBL197603 — — 1 6.83
CHEMBL217092 SARACATINIB 3.0 1 6.80
CHEMBL483847 — — 1 6.79
CHEMBL2041933 AZD-7762 1.0 1 6.78
CHEMBL1289926 AXITINIB 4.0 1 6.75
CHEMBL1801204 AZD-8055 1.0 1 6.74
CHEMBL2144069 — — 1 6.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1171837 PONATINIB IC50 = 0.1653 nM 9.78
CHEMBL325041 BORTEZOMIB IC50 = 3.489 nM 8.46
CHEMBL1201182 TEMSIROLIMUS IC50 = 4.033 nM 8.39
CHEMBL255863 NILOTINIB IC50 = 4.9 nM 8.31
CHEMBL159 VINBLASTINE IC50 = 7.015 nM 8.15
CHEMBL65 CAMPTOTHECIN IC50 = 7.02 nM 8.15
CHEMBL34259 METHOTREXATE IC50 = 12.39 nM 7.91
CHEMBL3545252 DOCETAXEL IC50 = 13.28 nM 7.88
CHEMBL94657 PATUPILONE IC50 = 18.88 nM 7.72
CHEMBL96926 THAPSIGARGIN IC50 = 19.44 nM 7.71
CHEMBL1256459 TORIN1 IC50 = 21.67 nM 7.66
CHEMBL1879463 DACTOLISIB IC50 = 35.87 nM 7.45
CHEMBL514499 GW843682X IC50 = 39.92 nM 7.40
CHEMBL252164 LUMINESPIB IC50 = 41.71 nM 7.38
CHEMBL553025 VINORELBINE IC50 = 45.75 nM 7.34
CHEMBL603469 LESTAURTINIB IC50 = 48.55 nM 7.31
CHEMBL1972860 ELESCLOMOL IC50 = 52.67 nM 7.28
CHEMBL449158 BRYOSTATIN 1 IC50 = 59.0 nM 7.23
CHEMBL941 IMATINIB IC50 = 73.04 nM 7.14
CHEMBL507361 MIRDAMETINIB IC50 = 94.68 nM 7.02
CHEMBL888 GEMCITABINE IC50 = 115.04 nM 6.94
CHEMBL428647 PACLITAXEL IC50 = 129.9 nM 6.89
CHEMBL513909 BI-2536 IC50 = 131.87 nM 6.88
CHEMBL197603 — IC50 = 146.57 nM 6.83
CHEMBL217092 SARACATINIB IC50 = 159.9 nM 6.80
CHEMBL483847 — IC50 = 162.64 nM 6.79
CHEMBL2041933 AZD-7762 IC50 = 165.03 nM 6.78
CHEMBL1289926 AXITINIB IC50 = 176.65 nM 6.75
CHEMBL1801204 AZD-8055 IC50 = 180.32 nM 6.74
CHEMBL2144069 — IC50 = 192.42 nM 6.72
CHEMBL300389 — IC50 = 203.14 nM 6.69
CHEMBL64925 MG-132 IC50 = 218.51 nM 6.66
CHEMBL189963 PALBOCICLIB IC50 = 258.19 nM 6.59
CHEMBL288441 BOSUTINIB IC50 = 286.64 nM 6.54
CHEMBL512504 — IC50 = 308.16 nM 6.51
CHEMBL3349342 — IC50 = 318.0 nM 6.50
CHEMBL803 CYTARABINE IC50 = 334.54 nM 6.48
CHEMBL572878 TOZASERTIB IC50 = 351.78 nM 6.45
CHEMBL53463 DOXORUBICIN IC50 = 437.3 nM 6.36
CHEMBL1614701 SELUMETINIB IC50 = 456.22 nM 6.34
CHEMBL443684 NAVITOCLAX IC50 = 592.07 nM 6.23
CHEMBL379300 A-443654 IC50 = 609.69 nM 6.21
CHEMBL105 MITOMYCIN IC50 = 641.66 nM 6.19
CHEMBL27759 ENTINOSTAT IC50 = 775.67 nM 6.11
CHEMBL188678 — IC50 = 988.33 nM 6.00
CHEMBL38 TRETINOIN IC50 = 996.35 nM 6.00
CHEMBL573107 — IC50 = 1127.94 nM 5.95
CHEMBL9470 SHIKONIN IC50 = 1209.53 nM 5.92
CHEMBL109480 TANESPIMYCIN IC50 = 1273.94 nM 5.89
CHEMBL1336 SORAFENIB IC50 = 1376.48 nM 5.86