Assay Detail
Functional
CHEMBL2363368
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human LB1047-RCC cell growth in a cell viability assay.
138
Total Activities
136
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LB1047-RCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 138 | 5.87 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 9.57 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.70 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.59 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.15 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.10 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.05 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 8.01 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.97 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.87 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.60 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.60 |
| CHEMBL514499 | GW843682X | — | 1 | 7.59 |
| CHEMBL300389 | — | — | 1 | 7.55 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 7.49 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.46 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.44 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.41 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.39 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.30 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.28 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 7.22 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.22 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.20 |
| CHEMBL213100 | — | — | 1 | 7.12 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.11 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.07 |
| CHEMBL379300 | A-443654 | — | 1 | 7.06 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.96 |
| CHEMBL197603 | — | — | 1 | 6.84 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.2688 | nM | 9.57 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.998 | nM | 8.70 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 2.566 | nM | 8.59 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 7.047 | nM | 8.15 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 7.897 | nM | 8.10 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 8.803 | nM | 8.05 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 9.887 | nM | 8.01 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 10.75 | nM | 7.97 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 25.1 | nM | 7.60 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 24.88 | nM | 7.60 |
| CHEMBL514499 | GW843682X | IC50 | = | 25.45 | nM | 7.59 |
| CHEMBL300389 | — | IC50 | = | 28.39 | nM | 7.55 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 32.55 | nM | 7.49 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 34.69 | nM | 7.46 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 35.97 | nM | 7.44 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 38.81 | nM | 7.41 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 40.27 | nM | 7.39 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 50.31 | nM | 7.30 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 52.96 | nM | 7.28 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 59.65 | nM | 7.22 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 60.25 | nM | 7.22 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 63.05 | nM | 7.20 |
| CHEMBL213100 | — | IC50 | = | 75.92 | nM | 7.12 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 76.91 | nM | 7.11 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 85.58 | nM | 7.07 |
| CHEMBL379300 | A-443654 | IC50 | = | 87.19 | nM | 7.06 |
| CHEMBL803 | CYTARABINE | IC50 | = | 108.42 | nM | 6.96 |
| CHEMBL197603 | — | IC50 | = | 143.45 | nM | 6.84 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 154.87 | nM | 6.81 |
| CHEMBL513909 | BI-2536 | IC50 | = | 244.1 | nM | 6.61 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 302.44 | nM | 6.52 |
| CHEMBL217354 | — | IC50 | = | 319.34 | nM | 6.50 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 340.47 | nM | 6.47 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 358.15 | nM | 6.45 |
| CHEMBL585951 | — | IC50 | = | 402.23 | nM | 6.40 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 522.93 | nM | 6.28 |
| CHEMBL509032 | TAE-684 | IC50 | = | 545.49 | nM | 6.26 |
| CHEMBL939 | GEFITINIB | IC50 | = | 625.29 | nM | 6.20 |
| CHEMBL401930 | — | IC50 | = | 641.57 | nM | 6.19 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 643.57 | nM | 6.19 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 721.56 | nM | 6.14 |
| CHEMBL1190711 | — | IC50 | = | 741.25 | nM | 6.13 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 735.38 | nM | 6.13 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 927.56 | nM | 6.03 |
| CHEMBL3349342 | — | IC50 | = | 1092.31 | nM | 5.96 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1183.12 | nM | 5.93 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1237.85 | nM | 5.91 |
| CHEMBL577784 | BX-795 | IC50 | = | 1292.81 | nM | 5.89 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 1554.53 | nM | 5.81 |