Assay Detail
Functional
CHEMBL2363369
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SANGER: Inhibition of human LB2241-RCC cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LB2241-RCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.76 | 10.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 10.50 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.10 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.68 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.28 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.26 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.00 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.88 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.85 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.44 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.41 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 7.26 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.25 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 7.21 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.18 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.18 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.00 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.96 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.90 |
| CHEMBL64925 | MG-132 | — | 2 | 6.85 |
| CHEMBL217354 | — | — | 1 | 6.83 |
| CHEMBL450786 | PHA-665752 | — | 1 | 6.80 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.71 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.63 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.52 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.52 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.45 |
| CHEMBL379975 | — | — | 1 | 6.40 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.28 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 6.27 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.03179 | nM | 10.50 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.8044 | nM | 9.10 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 2.076 | nM | 8.68 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 5.31 | nM | 8.28 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 5.548 | nM | 8.26 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 10.12 | nM | 8.00 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 13.19 | nM | 7.88 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 14.01 | nM | 7.85 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 36.42 | nM | 7.44 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 39.27 | nM | 7.41 |
| CHEMBL803 | CYTARABINE | IC50 | = | 55.34 | nM | 7.26 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 56.36 | nM | 7.25 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 61.02 | nM | 7.21 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 65.52 | nM | 7.18 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 66.04 | nM | 7.18 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 100.54 | nM | 7.00 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 108.84 | nM | 6.96 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 124.92 | nM | 6.90 |
| CHEMBL64925 | MG-132 | IC50 | = | 142.47 | nM | 6.85 |
| CHEMBL217354 | — | IC50 | = | 146.58 | nM | 6.83 |
| CHEMBL450786 | PHA-665752 | IC50 | = | 157.02 | nM | 6.80 |
| CHEMBL939 | GEFITINIB | IC50 | = | 194.93 | nM | 6.71 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 235.11 | nM | 6.63 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 301.98 | nM | 6.52 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 303.84 | nM | 6.52 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 352.41 | nM | 6.45 |
| CHEMBL379975 | — | IC50 | = | 394.33 | nM | 6.40 |
| CHEMBL513909 | BI-2536 | IC50 | = | 525.25 | nM | 6.28 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 537.18 | nM | 6.27 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 626.12 | nM | 6.20 |
| CHEMBL515416 | — | IC50 | = | 698.52 | nM | 6.16 |
| CHEMBL585951 | — | IC50 | = | 733.13 | nM | 6.13 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 738.25 | nM | 6.13 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 760.87 | nM | 6.12 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 789.91 | nM | 6.10 |
| CHEMBL64925 | MG-132 | IC50 | = | 870.76 | nM | 6.06 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 987.07 | nM | 6.01 |
| CHEMBL509032 | TAE-684 | IC50 | = | 988.4 | nM | 6.00 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 997.34 | nM | 6.00 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 1022.28 | nM | 5.99 |
| CHEMBL202721 | — | IC50 | = | 1041.89 | nM | 5.98 |
| CHEMBL554 | LAPATINIB | IC50 | = | 1154.03 | nM | 5.94 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 1186.2 | nM | 5.93 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1288.29 | nM | 5.89 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1286.63 | nM | 5.89 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 1318.21 | nM | 5.88 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1982.31 | nM | 5.70 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 2013.24 | nM | 5.70 |
| CHEMBL188678 | — | IC50 | = | 2141.46 | nM | 5.67 |
| CHEMBL2363137 | — | IC50 | = | 2612.25 | nM | 5.58 |