Assay Detail
Functional
CHEMBL2363370
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human LB2518-MEL cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LB2518-MEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.62 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.37 |
| CHEMBL2144069 | — | — | 1 | 8.32 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.95 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.76 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.75 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.67 |
| CHEMBL64925 | MG-132 | — | 2 | 7.42 |
| CHEMBL213100 | — | — | 1 | 7.33 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.19 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.17 |
| CHEMBL3349342 | — | — | 1 | 7.11 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.09 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.06 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.06 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 7.03 |
| CHEMBL514499 | GW843682X | — | 1 | 6.97 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 6.85 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.84 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.80 |
| CHEMBL217354 | — | — | 1 | 6.75 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.74 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.68 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.63 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.59 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.53 |
| CHEMBL379300 | A-443654 | — | 1 | 6.40 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.39 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.39 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.38 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.4248 | nM | 9.37 |
| CHEMBL2144069 | — | IC50 | = | 4.758 | nM | 8.32 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 11.13 | nM | 7.95 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 17.32 | nM | 7.76 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 17.61 | nM | 7.75 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 21.61 | nM | 7.67 |
| CHEMBL64925 | MG-132 | IC50 | = | 37.6 | nM | 7.42 |
| CHEMBL213100 | — | IC50 | = | 46.67 | nM | 7.33 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 64.52 | nM | 7.19 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 66.94 | nM | 7.17 |
| CHEMBL3349342 | — | IC50 | = | 77.51 | nM | 7.11 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 81.41 | nM | 7.09 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 87.25 | nM | 7.06 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 86.96 | nM | 7.06 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 93.82 | nM | 7.03 |
| CHEMBL514499 | GW843682X | IC50 | = | 107.14 | nM | 6.97 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 141.62 | nM | 6.85 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 145.03 | nM | 6.84 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 157.1 | nM | 6.80 |
| CHEMBL217354 | — | IC50 | = | 177.51 | nM | 6.75 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 182.25 | nM | 6.74 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 210.62 | nM | 6.68 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 233.72 | nM | 6.63 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 257.77 | nM | 6.59 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 293.42 | nM | 6.53 |
| CHEMBL379300 | A-443654 | IC50 | = | 397.21 | nM | 6.40 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 405.33 | nM | 6.39 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 408.72 | nM | 6.39 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 413.1 | nM | 6.38 |
| CHEMBL513909 | BI-2536 | IC50 | = | 497.03 | nM | 6.30 |
| CHEMBL585951 | — | IC50 | = | 540.14 | nM | 6.27 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 534.56 | nM | 6.27 |
| CHEMBL105442 | CI-1040 | IC50 | = | 716.32 | nM | 6.14 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 932.84 | nM | 6.03 |
| CHEMBL2363137 | — | IC50 | = | 1158.6 | nM | 5.94 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 1208.09 | nM | 5.92 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 1714.96 | nM | 5.77 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 2099.09 | nM | 5.68 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 2537.47 | nM | 5.60 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 2654.08 | nM | 5.58 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 2922.98 | nM | 5.53 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 3175.78 | nM | 5.50 |
| CHEMBL803 | CYTARABINE | IC50 | = | 3207.34 | nM | 5.49 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3223.98 | nM | 5.49 |
| CHEMBL300389 | — | IC50 | = | 3289.84 | nM | 5.48 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 3283.31 | nM | 5.48 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 3705.39 | nM | 5.43 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 5726.27 | nM | 5.24 |
| CHEMBL379975 | — | IC50 | = | 6344.66 | nM | 5.20 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 6257.12 | nM | 5.20 |