Assay Detail
Functional
CHEMBL2363372
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SANGER: Inhibition of human LB647-SCLC cell growth in a cell viability assay.
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LB647-SCLC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 5.77 | 8.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.93 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.51 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.37 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.31 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.16 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.98 |
| CHEMBL514499 | GW843682X | — | 1 | 7.72 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.50 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.93 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.91 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.81 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.67 |
| CHEMBL379300 | A-443654 | — | 1 | 6.65 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.63 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.62 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.48 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.47 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.43 |
| CHEMBL512504 | — | — | 1 | 6.21 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 5.98 |
| CHEMBL509032 | TAE-684 | — | 1 | 5.87 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 5.75 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.70 |
| CHEMBL64925 | MG-132 | — | 2 | 5.52 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.50 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.37 |
| CHEMBL197603 | — | — | 1 | 5.31 |
| CHEMBL259181 | — | — | 1 | 5.26 |
| CHEMBL585951 | — | — | 1 | 5.20 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 1.18 | nM | 8.93 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 3.096 | nM | 8.51 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 4.222 | nM | 8.37 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 4.861 | nM | 8.31 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 6.889 | nM | 8.16 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 10.51 | nM | 7.98 |
| CHEMBL514499 | GW843682X | IC50 | = | 18.94 | nM | 7.72 |
| CHEMBL513909 | BI-2536 | IC50 | = | 31.95 | nM | 7.50 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 117.05 | nM | 6.93 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 123.35 | nM | 6.91 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 154.9 | nM | 6.81 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 215.23 | nM | 6.67 |
| CHEMBL379300 | A-443654 | IC50 | = | 224.03 | nM | 6.65 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 232.78 | nM | 6.63 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 240.14 | nM | 6.62 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 328.71 | nM | 6.48 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 336.08 | nM | 6.47 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 367.3 | nM | 6.43 |
| CHEMBL512504 | — | IC50 | = | 622.41 | nM | 6.21 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1046.09 | nM | 5.98 |
| CHEMBL509032 | TAE-684 | IC50 | = | 1349.86 | nM | 5.87 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 1765.83 | nM | 5.75 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2001.19 | nM | 5.70 |
| CHEMBL64925 | MG-132 | IC50 | = | 3008.6 | nM | 5.52 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 3142.97 | nM | 5.50 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 4225.08 | nM | 5.37 |
| CHEMBL64925 | MG-132 | IC50 | = | 4563.08 | nM | 5.34 |
| CHEMBL197603 | — | IC50 | = | 4890.83 | nM | 5.31 |
| CHEMBL259181 | — | IC50 | = | 5490.36 | nM | 5.26 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 6369.83 | nM | 5.20 |
| CHEMBL585951 | — | IC50 | = | 6297.67 | nM | 5.20 |
| CHEMBL472940 | — | IC50 | = | 7296.53 | nM | 5.14 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 7932.78 | nM | 5.10 |
| CHEMBL300389 | — | IC50 | = | 9694.44 | nM | 5.01 |
| CHEMBL515416 | — | IC50 | = | 10856.11 | nM | 4.96 |
| CHEMBL1190711 | — | IC50 | = | 14066.51 | nM | 4.85 |
| CHEMBL401930 | — | IC50 | = | 14461.24 | nM | 4.84 |
| CHEMBL483847 | — | IC50 | = | 14886.61 | nM | 4.83 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 15719.52 | nM | 4.80 |
| CHEMBL554 | LAPATINIB | IC50 | = | 16937.19 | nM | 4.77 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 17494.89 | nM | 4.76 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 17772.58 | nM | 4.75 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 28336.65 | nM | 4.55 |
| CHEMBL591429 | PAC-1 | IC50 | = | 35212.28 | nM | 4.45 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 46215.49 | nM | 4.33 |
| CHEMBL373751 | GSK-319347A | IC50 | = | 54177.41 | nM | 4.27 |
| CHEMBL941 | IMATINIB | IC50 | = | 64118.82 | nM | 4.19 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 66308.76 | nM | 4.18 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 66590.37 | nM | 4.18 |
| CHEMBL209148 | — | IC50 | = | 92202.57 | nM | 4.04 |