Assay Detail
Functional
CHEMBL2363373
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SANGER: Inhibition of human LB771-HNC cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LB771-HNC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.43 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.32 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.07 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.07 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.07 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 7.64 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.60 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.55 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.22 |
| CHEMBL514499 | GW843682X | — | 1 | 7.22 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.19 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.12 |
| CHEMBL585951 | — | — | 1 | 7.11 |
| CHEMBL64925 | MG-132 | — | 2 | 7.09 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.99 |
| CHEMBL300389 | — | — | 1 | 6.79 |
| CHEMBL217354 | — | — | 1 | 6.78 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.71 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.70 |
| CHEMBL379300 | A-443654 | — | 1 | 6.65 |
| CHEMBL401930 | — | — | 1 | 6.64 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 6.59 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.54 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.53 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.25 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.11 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 6.08 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.07 |
| CHEMBL509032 | TAE-684 | — | 1 | 6.05 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.95 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.4744 | nM | 9.32 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 8.574 | nM | 8.07 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 8.591 | nM | 8.07 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 8.458 | nM | 8.07 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 22.96 | nM | 7.64 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 25.34 | nM | 7.60 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 28.37 | nM | 7.55 |
| CHEMBL513909 | BI-2536 | IC50 | = | 59.79 | nM | 7.22 |
| CHEMBL514499 | GW843682X | IC50 | = | 59.99 | nM | 7.22 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 64.12 | nM | 7.19 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 75.49 | nM | 7.12 |
| CHEMBL585951 | — | IC50 | = | 77.73 | nM | 7.11 |
| CHEMBL64925 | MG-132 | IC50 | = | 80.36 | nM | 7.09 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 102.55 | nM | 6.99 |
| CHEMBL300389 | — | IC50 | = | 160.59 | nM | 6.79 |
| CHEMBL217354 | — | IC50 | = | 165.94 | nM | 6.78 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 196.84 | nM | 6.71 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 200.18 | nM | 6.70 |
| CHEMBL379300 | A-443654 | IC50 | = | 222.39 | nM | 6.65 |
| CHEMBL401930 | — | IC50 | = | 230.32 | nM | 6.64 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 259.15 | nM | 6.59 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 285.84 | nM | 6.54 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 292.12 | nM | 6.53 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 559.33 | nM | 6.25 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 779.74 | nM | 6.11 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 831.04 | nM | 6.08 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 855.15 | nM | 6.07 |
| CHEMBL509032 | TAE-684 | IC50 | = | 897.57 | nM | 6.05 |
| CHEMBL64925 | MG-132 | IC50 | = | 1072.91 | nM | 5.97 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1128.55 | nM | 5.95 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1539.06 | nM | 5.81 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1951.02 | nM | 5.71 |
| CHEMBL848 | LENALIDOMIDE | IC50 | = | 2150.38 | nM | 5.67 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 2205.95 | nM | 5.66 |
| CHEMBL2363137 | — | IC50 | = | 2243.03 | nM | 5.65 |
| CHEMBL1023 | BEXAROTENE | IC50 | = | 2501.17 | nM | 5.60 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 2575.51 | nM | 5.59 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 2909.46 | nM | 5.54 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 3093.43 | nM | 5.51 |
| CHEMBL259181 | — | IC50 | = | 3250.26 | nM | 5.49 |
| CHEMBL939 | GEFITINIB | IC50 | = | 3391.26 | nM | 5.47 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 3435.35 | nM | 5.46 |
| CHEMBL379975 | — | IC50 | = | 5958.26 | nM | 5.22 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 6468.06 | nM | 5.19 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 6923.01 | nM | 5.16 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 7180.38 | nM | 5.14 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 8138.3 | nM | 5.09 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 8646.96 | nM | 5.06 |
| CHEMBL197603 | — | IC50 | = | 9530.63 | nM | 5.02 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 9764.97 | nM | 5.01 |