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Assay Detail

CHEMBL2363374

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Functional
SANGER: Inhibition of human LB831-BLC cell growth in a cell viability assay.
ChEMBL ↗
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type LB831-BLC
Confidence 1 — Organism
Curated By Autocuration

Target

LB831-BLC (CHEMBL2366222) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 139 5.60 9.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL325041 BORTEZOMIB 3.0 1 9.19
CHEMBL3545252 DOCETAXEL 4.0 1 8.83
CHEMBL96926 THAPSIGARGIN — 1 8.40
CHEMBL94657 PATUPILONE 3.0 1 8.22
CHEMBL65 CAMPTOTHECIN -1.0 1 7.74
CHEMBL159 VINBLASTINE 4.0 1 7.67
CHEMBL428647 PACLITAXEL 4.0 1 7.61
CHEMBL1972860 ELESCLOMOL 3.0 1 7.56
CHEMBL553025 VINORELBINE 4.0 1 7.54
CHEMBL300389 — — 1 7.49
CHEMBL252164 LUMINESPIB 2.0 1 7.49
CHEMBL888 GEMCITABINE 4.0 1 7.38
CHEMBL5416410 DASATINIB 4.0 1 7.34
CHEMBL513909 BI-2536 2.0 1 7.07
CHEMBL1879463 DACTOLISIB 3.0 1 6.92
CHEMBL213100 — — 1 6.90
CHEMBL109480 TANESPIMYCIN 3.0 1 6.86
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.85
CHEMBL1256459 TORIN1 — 1 6.79
CHEMBL64925 MG-132 — 2 6.71
CHEMBL379300 A-443654 — 1 6.71
CHEMBL514499 GW843682X — 1 6.70
CHEMBL53463 DOXORUBICIN 4.0 1 6.69
CHEMBL608533 MIDOSTAURIN 4.0 1 6.52
CHEMBL585951 — — 1 6.38
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.35
CHEMBL1201182 TEMSIROLIMUS 4.0 1 6.29
CHEMBL509032 TAE-684 — 1 6.26
CHEMBL197603 — — 1 6.23
CHEMBL217354 — — 1 6.13

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL325041 BORTEZOMIB IC50 = 0.6405 nM 9.19
CHEMBL3545252 DOCETAXEL IC50 = 1.479 nM 8.83
CHEMBL96926 THAPSIGARGIN IC50 = 3.945 nM 8.40
CHEMBL94657 PATUPILONE IC50 = 6.034 nM 8.22
CHEMBL65 CAMPTOTHECIN IC50 = 18.37 nM 7.74
CHEMBL159 VINBLASTINE IC50 = 21.23 nM 7.67
CHEMBL428647 PACLITAXEL IC50 = 24.85 nM 7.61
CHEMBL1972860 ELESCLOMOL IC50 = 27.72 nM 7.56
CHEMBL553025 VINORELBINE IC50 = 29.15 nM 7.54
CHEMBL300389 — IC50 = 32.47 nM 7.49
CHEMBL252164 LUMINESPIB IC50 = 32.19 nM 7.49
CHEMBL888 GEMCITABINE IC50 = 41.85 nM 7.38
CHEMBL5416410 DASATINIB IC50 = 46.09 nM 7.34
CHEMBL513909 BI-2536 IC50 = 85.61 nM 7.07
CHEMBL1879463 DACTOLISIB IC50 = 120.63 nM 6.92
CHEMBL213100 — IC50 = 127.15 nM 6.90
CHEMBL109480 TANESPIMYCIN IC50 = 138.83 nM 6.86
CHEMBL449158 BRYOSTATIN 1 IC50 = 141.94 nM 6.85
CHEMBL1256459 TORIN1 IC50 = 160.76 nM 6.79
CHEMBL64925 MG-132 IC50 = 193.4 nM 6.71
CHEMBL379300 A-443654 IC50 = 194.08 nM 6.71
CHEMBL514499 GW843682X IC50 = 199.94 nM 6.70
CHEMBL53463 DOXORUBICIN IC50 = 206.25 nM 6.69
CHEMBL608533 MIDOSTAURIN IC50 = 299.46 nM 6.52
CHEMBL585951 — IC50 = 419.52 nM 6.38
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 443.71 nM 6.35
CHEMBL64925 MG-132 IC50 = 476.26 nM 6.32
CHEMBL1201182 TEMSIROLIMUS IC50 = 514.57 nM 6.29
CHEMBL509032 TAE-684 IC50 = 550.23 nM 6.26
CHEMBL197603 — IC50 = 593.18 nM 6.23
CHEMBL217354 — IC50 = 744.78 nM 6.13
CHEMBL105 MITOMYCIN IC50 = 816.08 nM 6.09
CHEMBL1190711 — IC50 = 1020.39 nM 5.99
CHEMBL575448 BMS-754807 IC50 = 1346.39 nM 5.87
CHEMBL1801204 AZD-8055 IC50 = 1390.67 nM 5.86
CHEMBL401930 — IC50 = 1501.9 nM 5.82
CHEMBL1171837 PONATINIB IC50 = 1698.54 nM 5.77
CHEMBL34259 METHOTREXATE IC50 = 1711.51 nM 5.77
CHEMBL27759 ENTINOSTAT IC50 = 1835.63 nM 5.74
CHEMBL9470 SHIKONIN IC50 = 1916.8 nM 5.72
CHEMBL1084546 PF-00562271 IC50 = 2009.88 nM 5.70
CHEMBL2363137 — IC50 = 2098.22 nM 5.68
CHEMBL603469 LESTAURTINIB IC50 = 2319.26 nM 5.63
CHEMBL477772 PAZOPANIB IC50 = 2545.66 nM 5.59
CHEMBL289228 TIPIFARNIB IC50 = 2644.44 nM 5.58
CHEMBL1643959 — IC50 = 2948.91 nM 5.53
CHEMBL573107 — IC50 = 3540.16 nM 5.45
CHEMBL803 CYTARABINE IC50 = 4585.69 nM 5.34
CHEMBL135561 — IC50 = 4757.53 nM 5.32
CHEMBL191384 — IC50 = 5690.6 nM 5.25