Assay Detail
Functional
CHEMBL2363375
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SANGER: Inhibition of human LB996-RCC cell growth in a cell viability assay.
112
Total Activities
110
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LB996-RCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 112 | 5.65 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.47 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.22 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 8.00 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.94 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.75 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.57 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.50 |
| CHEMBL300389 | — | — | 1 | 7.49 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.33 |
| CHEMBL213100 | — | — | 1 | 7.25 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.19 |
| CHEMBL197603 | — | — | 1 | 7.13 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.11 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.11 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.03 |
| CHEMBL514499 | GW843682X | — | 1 | 6.98 |
| CHEMBL379300 | A-443654 | — | 1 | 6.91 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.76 |
| CHEMBL217354 | — | — | 1 | 6.60 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.51 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.47 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 6.40 |
| CHEMBL217092 | SARACATINIB | 3.0 | 1 | 6.36 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.33 |
| CHEMBL2165191 | AZD-6482 | 2.0 | 2 | 6.30 |
| CHEMBL585951 | — | — | 1 | 6.28 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.25 |
| CHEMBL509032 | TAE-684 | — | 1 | 6.16 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.15 |
| CHEMBL401930 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 3.401 | nM | 8.47 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 6.031 | nM | 8.22 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 9.912 | nM | 8.00 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 11.37 | nM | 7.94 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 17.68 | nM | 7.75 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 27.1 | nM | 7.57 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 31.32 | nM | 7.50 |
| CHEMBL300389 | — | IC50 | = | 32.54 | nM | 7.49 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 47.19 | nM | 7.33 |
| CHEMBL213100 | — | IC50 | = | 56.68 | nM | 7.25 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 65.09 | nM | 7.19 |
| CHEMBL197603 | — | IC50 | = | 74.57 | nM | 7.13 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 77.07 | nM | 7.11 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 78.45 | nM | 7.11 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 93.43 | nM | 7.03 |
| CHEMBL514499 | GW843682X | IC50 | = | 104.46 | nM | 6.98 |
| CHEMBL379300 | A-443654 | IC50 | = | 122.19 | nM | 6.91 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 175.34 | nM | 6.76 |
| CHEMBL217354 | — | IC50 | = | 250.01 | nM | 6.60 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 308.83 | nM | 6.51 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 336.19 | nM | 6.47 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 401.61 | nM | 6.40 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 441.96 | nM | 6.36 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 470.54 | nM | 6.33 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 498.58 | nM | 6.30 |
| CHEMBL585951 | — | IC50 | = | 521.54 | nM | 6.28 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 562.24 | nM | 6.25 |
| CHEMBL509032 | TAE-684 | IC50 | = | 693.89 | nM | 6.16 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 707.44 | nM | 6.15 |
| CHEMBL401930 | — | IC50 | = | 816.36 | nM | 6.09 |
| CHEMBL513909 | BI-2536 | IC50 | = | 1080.51 | nM | 5.97 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1221.77 | nM | 5.91 |
| CHEMBL554 | LAPATINIB | IC50 | = | 1362.28 | nM | 5.87 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1471.03 | nM | 5.83 |
| CHEMBL64925 | MG-132 | IC50 | = | 1552.79 | nM | 5.81 |
| CHEMBL1190711 | — | IC50 | = | 1703.22 | nM | 5.77 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 2138.17 | nM | 5.67 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 2195.1 | nM | 5.66 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 2898.6 | nM | 5.54 |
| CHEMBL191384 | — | IC50 | = | 2856.5 | nM | 5.54 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 3465.02 | nM | 5.46 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 3625.58 | nM | 5.44 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 3986.44 | nM | 5.40 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 3950.43 | nM | 5.40 |
| CHEMBL535 | SUNITINIB | IC50 | = | 4121.68 | nM | 5.38 |
| CHEMBL577784 | BX-795 | IC50 | = | 4507.1 | nM | 5.35 |
| CHEMBL2144069 | — | IC50 | = | 5289.58 | nM | 5.28 |
| CHEMBL1673039 | — | IC50 | = | 5374.64 | nM | 5.27 |
| CHEMBL92309 | — | IC50 | = | 6587.7 | nM | 5.18 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 7691.78 | nM | 5.11 |