Assay Detail
Functional
CHEMBL2363389
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SANGER: Inhibition of human LS-411N cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LS-411N |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.66 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.82 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.50 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.50 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.14 |
| CHEMBL514499 | GW843682X | — | 1 | 8.10 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.87 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.85 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.84 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.63 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.53 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.43 |
| CHEMBL300389 | — | — | 1 | 7.42 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 7.28 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.24 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.18 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.11 |
| CHEMBL379300 | A-443654 | — | 1 | 7.06 |
| CHEMBL2144069 | — | — | 1 | 7.04 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.00 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.99 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.93 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.84 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.74 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.73 |
| CHEMBL585951 | — | — | 1 | 6.70 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.49 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.49 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.47 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.42 |
| CHEMBL3349342 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 1.526 | nM | 8.82 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.139 | nM | 8.50 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 3.171 | nM | 8.50 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 7.166 | nM | 8.14 |
| CHEMBL514499 | GW843682X | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 13.63 | nM | 7.87 |
| CHEMBL513909 | BI-2536 | IC50 | = | 14.07 | nM | 7.85 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 14.39 | nM | 7.84 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 23.62 | nM | 7.63 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 29.88 | nM | 7.53 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 37.31 | nM | 7.43 |
| CHEMBL300389 | — | IC50 | = | 37.95 | nM | 7.42 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 52.76 | nM | 7.28 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 58.08 | nM | 7.24 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 66.35 | nM | 7.18 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 77.57 | nM | 7.11 |
| CHEMBL379300 | A-443654 | IC50 | = | 87.45 | nM | 7.06 |
| CHEMBL2144069 | — | IC50 | = | 91.61 | nM | 7.04 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 99.06 | nM | 7.00 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 101.77 | nM | 6.99 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 117.59 | nM | 6.93 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 142.95 | nM | 6.84 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 183.49 | nM | 6.74 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 187.28 | nM | 6.73 |
| CHEMBL585951 | — | IC50 | = | 198.46 | nM | 6.70 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 321.54 | nM | 6.49 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 321.76 | nM | 6.49 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 338.98 | nM | 6.47 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 376.06 | nM | 6.42 |
| CHEMBL3349342 | — | IC50 | = | 402.86 | nM | 6.39 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 434.44 | nM | 6.36 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 465.27 | nM | 6.33 |
| CHEMBL401930 | — | IC50 | = | 497.54 | nM | 6.30 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 577.52 | nM | 6.24 |
| CHEMBL509032 | TAE-684 | IC50 | = | 674.62 | nM | 6.17 |
| CHEMBL803 | CYTARABINE | IC50 | = | 695.27 | nM | 6.16 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 836.81 | nM | 6.08 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 925.38 | nM | 6.03 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1104.06 | nM | 5.96 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1150.17 | nM | 5.94 |
| CHEMBL217354 | — | IC50 | = | 1244.2 | nM | 5.91 |
| CHEMBL258844 | — | IC50 | = | 1246.55 | nM | 5.90 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1309.98 | nM | 5.88 |
| CHEMBL105442 | CI-1040 | IC50 | = | 1405.17 | nM | 5.85 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1521.54 | nM | 5.82 |
| CHEMBL64925 | MG-132 | IC50 | = | 1698.07 | nM | 5.77 |
| CHEMBL591429 | PAC-1 | IC50 | = | 2083.13 | nM | 5.68 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 2749.99 | nM | 5.56 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2823.3 | nM | 5.55 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 3189.61 | nM | 5.50 |