Assay Detail
Functional
CHEMBL2363397
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SANGER: Inhibition of human LXF-289 cell growth in a cell viability assay.
138
Total Activities
136
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LXF-289 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 138 | 5.72 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.64 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.57 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.12 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.48 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 8.38 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.33 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.15 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.09 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.99 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.85 |
| CHEMBL514499 | GW843682X | — | 1 | 7.79 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.75 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.58 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.57 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.54 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.40 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.26 |
| CHEMBL64925 | MG-132 | — | 2 | 7.15 |
| CHEMBL217354 | — | — | 1 | 7.14 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.96 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.83 |
| CHEMBL300389 | — | — | 1 | 6.78 |
| CHEMBL379300 | A-443654 | — | 1 | 6.75 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.75 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.60 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.60 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.58 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.48 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.39 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.2269 | nM | 9.64 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.2688 | nM | 9.57 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.7581 | nM | 9.12 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 3.314 | nM | 8.48 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 4.192 | nM | 8.38 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 4.685 | nM | 8.33 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 7.054 | nM | 8.15 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 8.184 | nM | 8.09 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 10.29 | nM | 7.99 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 14.04 | nM | 7.85 |
| CHEMBL514499 | GW843682X | IC50 | = | 16.22 | nM | 7.79 |
| CHEMBL513909 | BI-2536 | IC50 | = | 17.7 | nM | 7.75 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 26.04 | nM | 7.58 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 26.68 | nM | 7.57 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 28.72 | nM | 7.54 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 39.56 | nM | 7.40 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 55.37 | nM | 7.26 |
| CHEMBL64925 | MG-132 | IC50 | = | 70.66 | nM | 7.15 |
| CHEMBL217354 | — | IC50 | = | 72.85 | nM | 7.14 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 109.24 | nM | 6.96 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 148.34 | nM | 6.83 |
| CHEMBL300389 | — | IC50 | = | 164.45 | nM | 6.78 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 177.88 | nM | 6.75 |
| CHEMBL379300 | A-443654 | IC50 | = | 179.4 | nM | 6.75 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 250.41 | nM | 6.60 |
| CHEMBL803 | CYTARABINE | IC50 | = | 251.41 | nM | 6.60 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 259.84 | nM | 6.58 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 329.65 | nM | 6.48 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 404.06 | nM | 6.39 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 448.27 | nM | 6.35 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 644.25 | nM | 6.19 |
| CHEMBL577784 | BX-795 | IC50 | = | 656.93 | nM | 6.18 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 676.25 | nM | 6.17 |
| CHEMBL197603 | — | IC50 | = | 757.17 | nM | 6.12 |
| CHEMBL585951 | — | IC50 | = | 797.33 | nM | 6.10 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 959.01 | nM | 6.02 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 977.22 | nM | 6.01 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 1023.16 | nM | 5.99 |
| CHEMBL509032 | TAE-684 | IC50 | = | 1030.76 | nM | 5.99 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 1171.56 | nM | 5.93 |
| CHEMBL213100 | — | IC50 | = | 1272.56 | nM | 5.89 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1352.4 | nM | 5.87 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 1401.52 | nM | 5.85 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 1439.96 | nM | 5.84 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 1551.04 | nM | 5.81 |
| CHEMBL401930 | — | IC50 | = | 1551.73 | nM | 5.81 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 1732.68 | nM | 5.76 |
| CHEMBL258844 | — | IC50 | = | 1760.67 | nM | 5.75 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2075.22 | nM | 5.68 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 2354.74 | nM | 5.63 |