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Assay Detail

CHEMBL2363400

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Functional
SANGER: Inhibition of human M14 cell growth in a cell viability assay.
ChEMBL ↗
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type M14
Confidence 1 — Organism
Curated By Autocuration

Target

M14 (CHEMBL614317) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 99 5.79 8.84

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL507361 MIRDAMETINIB 2.0 1 8.84
CHEMBL3545252 DOCETAXEL 4.0 1 8.72
CHEMBL159 VINBLASTINE 4.0 1 8.50
CHEMBL65 CAMPTOTHECIN -1.0 1 8.00
CHEMBL449158 BRYOSTATIN 1 2.0 1 7.94
CHEMBL96926 THAPSIGARGIN — 1 7.85
CHEMBL553025 VINORELBINE 4.0 1 7.67
CHEMBL3349342 — — 1 7.54
CHEMBL94657 PATUPILONE 3.0 1 7.43
CHEMBL1614701 SELUMETINIB 4.0 1 7.43
CHEMBL603469 LESTAURTINIB 3.0 1 7.30
CHEMBL1879463 DACTOLISIB 3.0 1 7.22
CHEMBL109480 TANESPIMYCIN 3.0 1 7.10
CHEMBL477989 SB590885 — 1 7.09
CHEMBL1972860 ELESCLOMOL 3.0 1 6.91
CHEMBL2041933 AZD-7762 1.0 1 6.84
CHEMBL105442 CI-1040 2.0 1 6.81
CHEMBL252164 LUMINESPIB 2.0 1 6.66
CHEMBL1230020 PLX-4720 — 1 6.66
CHEMBL585951 — — 1 6.47
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.34
CHEMBL1801204 AZD-8055 1.0 1 6.33
CHEMBL1201182 TEMSIROLIMUS 4.0 1 6.33
CHEMBL888 GEMCITABINE 4.0 1 6.29
CHEMBL803 CYTARABINE 4.0 1 6.20
CHEMBL53463 DOXORUBICIN 4.0 1 6.04
CHEMBL105 MITOMYCIN 4.0 1 5.87
CHEMBL9470 SHIKONIN — 1 5.83
CHEMBL379975 — — 1 5.77
CHEMBL34259 METHOTREXATE 4.0 1 5.71

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL507361 MIRDAMETINIB IC50 = 1.448 nM 8.84
CHEMBL3545252 DOCETAXEL IC50 = 1.906 nM 8.72
CHEMBL159 VINBLASTINE IC50 = 3.191 nM 8.50
CHEMBL65 CAMPTOTHECIN IC50 = 9.948 nM 8.00
CHEMBL449158 BRYOSTATIN 1 IC50 = 11.43 nM 7.94
CHEMBL96926 THAPSIGARGIN IC50 = 14.0 nM 7.85
CHEMBL553025 VINORELBINE IC50 = 21.12 nM 7.67
CHEMBL3349342 — IC50 = 28.6 nM 7.54
CHEMBL94657 PATUPILONE IC50 = 37.33 nM 7.43
CHEMBL1614701 SELUMETINIB IC50 = 36.89 nM 7.43
CHEMBL603469 LESTAURTINIB IC50 = 50.56 nM 7.30
CHEMBL1879463 DACTOLISIB IC50 = 60.04 nM 7.22
CHEMBL109480 TANESPIMYCIN IC50 = 79.13 nM 7.10
CHEMBL477989 SB590885 IC50 = 80.77 nM 7.09
CHEMBL1972860 ELESCLOMOL IC50 = 122.31 nM 6.91
CHEMBL2041933 AZD-7762 IC50 = 144.63 nM 6.84
CHEMBL105442 CI-1040 IC50 = 154.68 nM 6.81
CHEMBL252164 LUMINESPIB IC50 = 218.03 nM 6.66
CHEMBL1230020 PLX-4720 IC50 = 217.57 nM 6.66
CHEMBL585951 — IC50 = 341.95 nM 6.47
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 459.79 nM 6.34
CHEMBL1801204 AZD-8055 IC50 = 471.7 nM 6.33
CHEMBL1201182 TEMSIROLIMUS IC50 = 463.06 nM 6.33
CHEMBL888 GEMCITABINE IC50 = 514.66 nM 6.29
CHEMBL803 CYTARABINE IC50 = 632.24 nM 6.20
CHEMBL53463 DOXORUBICIN IC50 = 905.27 nM 6.04
CHEMBL105 MITOMYCIN IC50 = 1337.6 nM 5.87
CHEMBL9470 SHIKONIN IC50 = 1492.69 nM 5.83
CHEMBL379975 — IC50 = 1694.33 nM 5.77
CHEMBL34259 METHOTREXATE IC50 = 1942.98 nM 5.71
CHEMBL98 VORINOSTAT IC50 = 2669.93 nM 5.57
CHEMBL217354 — IC50 = 2827.53 nM 5.55
CHEMBL11359 CISPLATIN IC50 = 2789.69 nM 5.55
CHEMBL6067492 BLEOMYCIN IC50 = 3224.56 nM 5.49
CHEMBL521851 PICTILISIB IC50 = 3306.63 nM 5.48
CHEMBL288441 BOSUTINIB IC50 = 4487.92 nM 5.35
CHEMBL577784 BX-795 IC50 = 5224.37 nM 5.28
CHEMBL573107 — IC50 = 5867.26 nM 5.23
CHEMBL575448 BMS-754807 IC50 = 6588.61 nM 5.18
CHEMBL44657 ETOPOSIDE IC50 = 7945.38 nM 5.10
CHEMBL512504 — IC50 = 10522.42 nM 4.98
CHEMBL221137 EMBELIN IC50 = 11006.31 nM 4.96
CHEMBL202721 — IC50 = 11797.21 nM 4.93
CHEMBL188678 — IC50 = 13033.47 nM 4.88
CHEMBL608533 MIDOSTAURIN IC50 = 15845.17 nM 4.80
CHEMBL2165191 AZD-6482 IC50 = 20625.04 nM 4.69
CHEMBL412142 LADUVIGLUSIB IC50 = 23113.2 nM 4.64
CHEMBL1079175 MK-2206 IC50 = 23408.75 nM 4.63
CHEMBL939 GEFITINIB IC50 = 25444.74 nM 4.59
CHEMBL191384 — IC50 = 28424.06 nM 4.55