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Assay Detail

CHEMBL2363402

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Functional
SANGER: Inhibition of human MC-IXC cell growth in a cell viability assay.
ChEMBL ↗
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MC-IXC
Confidence 1 — Organism
Curated By Autocuration

Target

MC-IXC (CHEMBL1075495) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 99 5.84 9.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3545252 DOCETAXEL 4.0 1 9.32
CHEMBL65 CAMPTOTHECIN -1.0 1 9.29
CHEMBL105 MITOMYCIN 4.0 1 9.20
CHEMBL553025 VINORELBINE 4.0 1 8.83
CHEMBL888 GEMCITABINE 4.0 1 8.64
CHEMBL159 VINBLASTINE 4.0 1 8.53
CHEMBL94657 PATUPILONE 3.0 1 8.52
CHEMBL1972860 ELESCLOMOL 3.0 1 8.14
CHEMBL603469 LESTAURTINIB 3.0 1 7.87
CHEMBL449158 BRYOSTATIN 1 2.0 1 7.85
CHEMBL252164 LUMINESPIB 2.0 1 7.76
CHEMBL96926 THAPSIGARGIN — 1 7.42
CHEMBL803 CYTARABINE 4.0 1 7.38
CHEMBL53463 DOXORUBICIN 4.0 1 7.17
CHEMBL1879463 DACTOLISIB 3.0 1 7.15
CHEMBL217354 — — 1 7.12
CHEMBL44657 ETOPOSIDE 4.0 1 6.94
CHEMBL585951 — — 1 6.90
CHEMBL2041933 AZD-7762 1.0 1 6.89
CHEMBL38 TRETINOIN 4.0 1 6.81
CHEMBL575448 BMS-754807 2.0 1 6.75
CHEMBL608533 MIDOSTAURIN 4.0 1 6.58
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.46
CHEMBL9470 SHIKONIN — 1 6.41
CHEMBL1801204 AZD-8055 1.0 1 6.14
CHEMBL573107 — — 1 6.10
CHEMBL477772 PAZOPANIB 4.0 1 5.95
CHEMBL98 VORINOSTAT 4.0 1 5.93
CHEMBL109480 TANESPIMYCIN 3.0 1 5.85
CHEMBL11359 CISPLATIN 4.0 1 5.78

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3545252 DOCETAXEL IC50 = 0.4789 nM 9.32
CHEMBL65 CAMPTOTHECIN IC50 = 0.513 nM 9.29
CHEMBL105 MITOMYCIN IC50 = 0.638 nM 9.20
CHEMBL553025 VINORELBINE IC50 = 1.486 nM 8.83
CHEMBL888 GEMCITABINE IC50 = 2.264 nM 8.64
CHEMBL159 VINBLASTINE IC50 = 2.985 nM 8.53
CHEMBL94657 PATUPILONE IC50 = 3.056 nM 8.52
CHEMBL1972860 ELESCLOMOL IC50 = 7.171 nM 8.14
CHEMBL603469 LESTAURTINIB IC50 = 13.45 nM 7.87
CHEMBL449158 BRYOSTATIN 1 IC50 = 14.16 nM 7.85
CHEMBL252164 LUMINESPIB IC50 = 17.36 nM 7.76
CHEMBL96926 THAPSIGARGIN IC50 = 37.61 nM 7.42
CHEMBL803 CYTARABINE IC50 = 41.41 nM 7.38
CHEMBL53463 DOXORUBICIN IC50 = 67.9 nM 7.17
CHEMBL1879463 DACTOLISIB IC50 = 70.08 nM 7.15
CHEMBL217354 — IC50 = 75.33 nM 7.12
CHEMBL44657 ETOPOSIDE IC50 = 115.12 nM 6.94
CHEMBL585951 — IC50 = 126.71 nM 6.90
CHEMBL2041933 AZD-7762 IC50 = 128.43 nM 6.89
CHEMBL38 TRETINOIN IC50 = 154.36 nM 6.81
CHEMBL575448 BMS-754807 IC50 = 179.96 nM 6.75
CHEMBL608533 MIDOSTAURIN IC50 = 266.29 nM 6.58
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 345.0 nM 6.46
CHEMBL9470 SHIKONIN IC50 = 387.38 nM 6.41
CHEMBL1801204 AZD-8055 IC50 = 727.18 nM 6.14
CHEMBL573107 — IC50 = 795.89 nM 6.10
CHEMBL477772 PAZOPANIB IC50 = 1115.12 nM 5.95
CHEMBL98 VORINOSTAT IC50 = 1178.81 nM 5.93
CHEMBL109480 TANESPIMYCIN IC50 = 1423.71 nM 5.85
CHEMBL11359 CISPLATIN IC50 = 1679.32 nM 5.78
CHEMBL1091644 LINSITINIB IC50 = 1989.8 nM 5.70
CHEMBL1171837 PONATINIB IC50 = 2022.73 nM 5.69
CHEMBL1201182 TEMSIROLIMUS IC50 = 2031.53 nM 5.69
CHEMBL258844 — IC50 = 2056.65 nM 5.69
CHEMBL379975 — IC50 = 2490.71 nM 5.60
CHEMBL2363137 — IC50 = 2508.94 nM 5.60
CHEMBL939 GEFITINIB IC50 = 2644.53 nM 5.58
CHEMBL289228 TIPIFARNIB IC50 = 2761.92 nM 5.56
CHEMBL2137530 SERDEMETAN IC50 = 2877.92 nM 5.54
CHEMBL577784 BX-795 IC50 = 2895.3 nM 5.54
CHEMBL6067492 BLEOMYCIN IC50 = 2996.93 nM 5.52
CHEMBL1173055 RUCAPARIB IC50 = 3546.24 nM 5.45
CHEMBL521686 OLAPARIB IC50 = 3633.93 nM 5.44
CHEMBL591429 PAC-1 IC50 = 5108.72 nM 5.29
CHEMBL221137 EMBELIN IC50 = 5391.02 nM 5.27
CHEMBL1079175 MK-2206 IC50 = 7485.76 nM 5.13
CHEMBL521851 PICTILISIB IC50 = 7419.72 nM 5.13
CHEMBL1023 BEXAROTENE IC50 = 7973.5 nM 5.10
CHEMBL507361 MIRDAMETINIB IC50 = 9531.29 nM 5.02
CHEMBL34259 METHOTREXATE IC50 = 9512.89 nM 5.02