Assay Detail
Functional
CHEMBL2363406
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SANGER: Inhibition of human MDA-MB-157 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-157 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.40 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.54 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.12 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.04 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.63 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.45 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 7.06 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.00 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.74 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.67 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.56 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.38 |
| CHEMBL585951 | — | — | 1 | 6.34 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.30 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.20 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.17 |
| CHEMBL217354 | — | — | 1 | 6.08 |
| CHEMBL512504 | — | — | 1 | 6.08 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.08 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 6.02 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.86 |
| CHEMBL577784 | BX-795 | — | 1 | 5.76 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.66 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 5.65 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.57 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.55 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.49 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 5.48 |
| CHEMBL573107 | — | — | 1 | 5.37 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 5.31 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 2.918 | nM | 8.54 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 7.569 | nM | 8.12 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 9.064 | nM | 8.04 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 23.49 | nM | 7.63 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 35.41 | nM | 7.45 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 86.59 | nM | 7.06 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 98.78 | nM | 7.00 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 180.82 | nM | 6.74 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 212.56 | nM | 6.67 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 275.72 | nM | 6.56 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 420.15 | nM | 6.38 |
| CHEMBL585951 | — | IC50 | = | 457.17 | nM | 6.34 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 499.01 | nM | 6.30 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 636.63 | nM | 6.20 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 678.1 | nM | 6.17 |
| CHEMBL217354 | — | IC50 | = | 841.37 | nM | 6.08 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 822.71 | nM | 6.08 |
| CHEMBL512504 | — | IC50 | = | 824.06 | nM | 6.08 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 945.71 | nM | 6.02 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1389.17 | nM | 5.86 |
| CHEMBL577784 | BX-795 | IC50 | = | 1716.74 | nM | 5.76 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 2192.54 | nM | 5.66 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 2218.28 | nM | 5.65 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 2707.47 | nM | 5.57 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 2820.23 | nM | 5.55 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 3245.93 | nM | 5.49 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 3329.18 | nM | 5.48 |
| CHEMBL573107 | — | IC50 | = | 4306.56 | nM | 5.37 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 4887.6 | nM | 5.31 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 5664.43 | nM | 5.25 |
| CHEMBL202721 | — | IC50 | = | 6415.19 | nM | 5.19 |
| CHEMBL221137 | EMBELIN | IC50 | = | 6881.91 | nM | 5.16 |
| CHEMBL191384 | — | IC50 | = | 7071.74 | nM | 5.15 |
| CHEMBL2363137 | — | IC50 | = | 8592.51 | nM | 5.07 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 9928.78 | nM | 5.00 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 10576.86 | nM | 4.98 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 12609.43 | nM | 4.90 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 13940.89 | nM | 4.86 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 13960.08 | nM | 4.86 |
| CHEMBL1090771 | AVAGACESTAT | IC50 | = | 14243.15 | nM | 4.85 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 14671.87 | nM | 4.83 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 19987.06 | nM | 4.70 |
| CHEMBL572881 | MOTESANIB | IC50 | = | 21382.48 | nM | 4.67 |
| CHEMBL399530 | — | IC50 | = | 22048.8 | nM | 4.66 |
| CHEMBL3349342 | — | IC50 | = | 22412.19 | nM | 4.65 |
| CHEMBL379975 | — | IC50 | = | 26207.9 | nM | 4.58 |
| CHEMBL105442 | CI-1040 | IC50 | = | 27875.27 | nM | 4.55 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 27927.42 | nM | 4.55 |
| CHEMBL939 | GEFITINIB | IC50 | = | 34819.34 | nM | 4.46 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 38553.31 | nM | 4.41 |