Assay Detail
Functional
CHEMBL2363409
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SANGER: Inhibition of human MDA-MB-361 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-361 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.49 | 8.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.78 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.55 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.32 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.01 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.83 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.78 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.59 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.46 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.23 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.21 |
| CHEMBL217354 | — | — | 1 | 6.64 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.60 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.53 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.52 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.36 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.34 |
| CHEMBL258844 | — | — | 1 | 6.31 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.29 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 6.24 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.14 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.14 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.09 |
| CHEMBL512504 | — | — | 1 | 6.07 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.00 |
| CHEMBL585951 | — | — | 1 | 5.97 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 5.90 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 5.84 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.83 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.76 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 1.662 | nM | 8.78 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 2.813 | nM | 8.55 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 4.729 | nM | 8.32 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 9.759 | nM | 8.01 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 14.95 | nM | 7.83 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 16.53 | nM | 7.78 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 25.89 | nM | 7.59 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 34.43 | nM | 7.46 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 58.72 | nM | 7.23 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL217354 | — | IC50 | = | 226.4 | nM | 6.64 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 248.74 | nM | 6.60 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 292.65 | nM | 6.53 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 298.96 | nM | 6.52 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 439.13 | nM | 6.36 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 460.64 | nM | 6.34 |
| CHEMBL258844 | — | IC50 | = | 489.95 | nM | 6.31 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 508.7 | nM | 6.29 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 577.61 | nM | 6.24 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 726.62 | nM | 6.14 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 719.09 | nM | 6.14 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 808.98 | nM | 6.09 |
| CHEMBL512504 | — | IC50 | = | 860.48 | nM | 6.07 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 997.77 | nM | 6.00 |
| CHEMBL585951 | — | IC50 | = | 1072.79 | nM | 5.97 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 1248.83 | nM | 5.90 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 1453.89 | nM | 5.84 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 1495.36 | nM | 5.83 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1732.36 | nM | 5.76 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1731.57 | nM | 5.76 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 2114.43 | nM | 5.67 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 3527.09 | nM | 5.45 |
| CHEMBL2363137 | — | IC50 | = | 3658.25 | nM | 5.44 |
| CHEMBL803 | CYTARABINE | IC50 | = | 4227.26 | nM | 5.37 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 4331.53 | nM | 5.36 |
| CHEMBL1090090 | VX-702 | IC50 | = | 4431.58 | nM | 5.35 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 5986.47 | nM | 5.22 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 6092.61 | nM | 5.21 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 6336.99 | nM | 5.20 |
| CHEMBL191384 | — | IC50 | = | 6494.69 | nM | 5.19 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 6475.71 | nM | 5.19 |
| CHEMBL202721 | — | IC50 | = | 7344.94 | nM | 5.13 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 8182.4 | nM | 5.09 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 8543.39 | nM | 5.07 |
| CHEMBL135561 | — | IC50 | = | 8479.85 | nM | 5.07 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 10443.25 | nM | 4.98 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 12293.79 | nM | 4.91 |
| CHEMBL1190711 | — | IC50 | = | 13754.32 | nM | 4.86 |
| CHEMBL3349342 | — | IC50 | = | 15512.82 | nM | 4.81 |
| CHEMBL473417 | VISMODEGIB | IC50 | = | 17271.06 | nM | 4.76 |