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Target Snapshot

CHEMBL614129 Target Snapshot

MDA-MB-361 · CELL-LINE · Homo sapiens

503Compounds
157Assays
33Approved Drugs
434.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats MDA-MB-361 as ChEMBL target CHEMBL614129. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
MDA-MB-361
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614129
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether MDA-MB-361 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMDA-MB-361
UniProt AccessionN/A

MDA-MB-361

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as MDA-MB-361.

Review nameMDA-MB-361
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

33
Approved
14
Phase III
12
Phase II
6
Phase I
Assay Mix

Activity Type Distribution

IC50415.0
EC5019.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL159 8.78 IC50 1.662 Approved
CHEMBL3545252 8.55 IC50 2.813 Approved
CHEMBL1095627 8.55 IC50 2.8 Preclinical
CHEMBL1808977 8.52 IC50 3.0 Preclinical
CHEMBL592619 8.52 IC50 3.0 Preclinical
CHEMBL592461 8.52 IC50 3.0 Preclinical
CHEMBL592445 8.52 IC50 3.0 Clinical
CHEMBL592615 8.52 IC50 3.0 Preclinical
CHEMBL1808988 8.4 IC50 4.0 Preclinical
CHEMBL1808984 8.4 IC50 4.0 Preclinical
Distribution

pChEMBL Value Distribution

47
5.0
22
5.5
24
6.0
38
6.5
40
7.0
43
7.5
26
8.0
8
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ABEMACICLIB
CHEMBL3301610
Approved 2017
AFATINIB
CHEMBL1173655
Approved 2013
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
MITOMYCIN
CHEMBL105
Approved 1981
DAUNORUBICIN
CHEMBL178
Approved 1979
DOXORUBICIN
CHEMBL53463
Approved 1974
VINBLASTINE
CHEMBL159
Approved 1965
Assay Landscape

Assay Landscape

157
Total Assays
342
Tested Compounds
4
Assay Types
Functional — 149 assays, 342 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 116 342 6.0
organism-based format 33 0
Toxicity — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 0
Unassigned — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 0
ADME — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine