Assay Detail
Functional
CHEMBL2363414
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SANGER: Inhibition of human MEG-01 cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MEG-01 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.87 | 10.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL213100 | — | — | 1 | 10.79 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 9.89 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.90 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.82 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.46 |
| CHEMBL255863 | NILOTINIB | 4.0 | 1 | 8.08 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.97 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.83 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.76 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.68 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.53 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.40 |
| CHEMBL514499 | GW843682X | — | 1 | 7.38 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.20 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.05 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 7.05 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.01 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.00 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.98 |
| CHEMBL300389 | — | — | 1 | 6.90 |
| CHEMBL197603 | — | — | 1 | 6.77 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.76 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.75 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.73 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.70 |
| CHEMBL217092 | SARACATINIB | 3.0 | 1 | 6.62 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.59 |
| CHEMBL512504 | — | — | 1 | 6.57 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.56 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213100 | — | IC50 | = | 0.01626 | nM | 10.79 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 0.1276 | nM | 9.89 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 1.266 | nM | 8.90 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.525 | nM | 8.82 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 3.489 | nM | 8.46 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 8.283 | nM | 8.08 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 10.78 | nM | 7.97 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 14.74 | nM | 7.83 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 17.37 | nM | 7.76 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 29.78 | nM | 7.53 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 39.51 | nM | 7.40 |
| CHEMBL514499 | GW843682X | IC50 | = | 41.93 | nM | 7.38 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 63.52 | nM | 7.20 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 88.16 | nM | 7.05 |
| CHEMBL941 | IMATINIB | IC50 | = | 89.21 | nM | 7.05 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 97.77 | nM | 7.01 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 99.44 | nM | 7.00 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 105.05 | nM | 6.98 |
| CHEMBL300389 | — | IC50 | = | 126.03 | nM | 6.90 |
| CHEMBL197603 | — | IC50 | = | 168.99 | nM | 6.77 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 172.57 | nM | 6.76 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 176.6 | nM | 6.75 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 186.28 | nM | 6.73 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 201.96 | nM | 6.70 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 236.88 | nM | 6.62 |
| CHEMBL513909 | BI-2536 | IC50 | = | 256.73 | nM | 6.59 |
| CHEMBL512504 | — | IC50 | = | 268.7 | nM | 6.57 |
| CHEMBL939 | GEFITINIB | IC50 | = | 276.76 | nM | 6.56 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 278.49 | nM | 6.55 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 345.84 | nM | 6.46 |
| CHEMBL2144069 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 395.49 | nM | 6.40 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 423.61 | nM | 6.37 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 436.44 | nM | 6.36 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 451.25 | nM | 6.35 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 453.73 | nM | 6.34 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 455.78 | nM | 6.34 |
| CHEMBL483847 | — | IC50 | = | 503.36 | nM | 6.30 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 512.14 | nM | 6.29 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 583.2 | nM | 6.23 |
| CHEMBL585951 | — | IC50 | = | 683.84 | nM | 6.17 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 683.36 | nM | 6.17 |
| CHEMBL3349342 | — | IC50 | = | 785.84 | nM | 6.11 |
| CHEMBL379300 | A-443654 | IC50 | = | 813.84 | nM | 6.09 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 857.66 | nM | 6.07 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1221.18 | nM | 5.91 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 1629.59 | nM | 5.79 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1799.15 | nM | 5.75 |
| CHEMBL535 | SUNITINIB | IC50 | = | 1835.63 | nM | 5.74 |