Assay Detail
Functional
CHEMBL2363417
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human MES-SA cell growth in a cell viability assay.
47
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MES-SA |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 5.99 | 10.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 10.57 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 9.04 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.70 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.51 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.35 |
| CHEMBL9470 | SHIKONIN | — | 1 | 7.38 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 7.12 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.00 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.84 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.62 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.42 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.39 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.34 |
| CHEMBL585951 | — | — | 1 | 6.14 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.06 |
| CHEMBL1190711 | — | — | 1 | 6.02 |
| CHEMBL2165191 | AZD-6482 | 2.0 | 2 | 5.96 |
| CHEMBL217354 | — | — | 1 | 5.96 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 5.88 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.78 |
| CHEMBL258844 | — | — | 1 | 5.55 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.34 |
| CHEMBL191384 | — | — | 1 | 5.33 |
| CHEMBL558642 | GSK-650394 | — | 1 | 5.25 |
| CHEMBL477772 | PAZOPANIB | 4.0 | 1 | 4.88 |
| CHEMBL221137 | EMBELIN | — | 1 | 4.78 |
| CHEMBL399530 | — | — | 1 | 4.65 |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | 4.63 |
| CHEMBL472940 | — | — | 1 | 4.62 |
| CHEMBL259181 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.02681 | nM | 10.57 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.9049 | nM | 9.04 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.975 | nM | 8.70 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 3.115 | nM | 8.51 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 4.52 | nM | 8.35 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 41.32 | nM | 7.38 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 75.44 | nM | 7.12 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 99.53 | nM | 7.00 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 144.94 | nM | 6.84 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 241.87 | nM | 6.62 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 379.82 | nM | 6.42 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 405.05 | nM | 6.39 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 458.21 | nM | 6.34 |
| CHEMBL585951 | — | IC50 | = | 716.9 | nM | 6.14 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 873.72 | nM | 6.06 |
| CHEMBL1190711 | — | IC50 | = | 959.91 | nM | 6.02 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 1105.67 | nM | 5.96 |
| CHEMBL217354 | — | IC50 | = | 1109.97 | nM | 5.96 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 1306.82 | nM | 5.88 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 1673.44 | nM | 5.78 |
| CHEMBL258844 | — | IC50 | = | 2787.97 | nM | 5.55 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 4611.06 | nM | 5.34 |
| CHEMBL191384 | — | IC50 | = | 4672.22 | nM | 5.33 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 5564.46 | nM | 5.25 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 11911.56 | nM | 4.92 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 13234.63 | nM | 4.88 |
| CHEMBL221137 | EMBELIN | IC50 | = | 16517.41 | nM | 4.78 |
| CHEMBL399530 | — | IC50 | = | 22191.05 | nM | 4.65 |
| CHEMBL591429 | PAC-1 | IC50 | = | 23626.34 | nM | 4.63 |
| CHEMBL472940 | — | IC50 | = | 23872.73 | nM | 4.62 |
| CHEMBL259181 | — | IC50 | = | 28520.44 | nM | 4.54 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 31652.65 | nM | 4.50 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 34603.92 | nM | 4.46 |
| CHEMBL512504 | — | IC50 | = | 46512.12 | nM | 4.33 |
| CHEMBL2134202 | — | IC50 | = | 59450.91 | nM | 4.23 |
| CHEMBL135561 | — | IC50 | = | 62167.1 | nM | 4.21 |
| CHEMBL1090771 | AVAGACESTAT | IC50 | = | 63123.87 | nM | 4.20 |
| CHEMBL92309 | — | IC50 | = | 1066394.91 | nM | - |
| CHEMBL228043 | — | IC50 | = | 2500019.97 | nM | - |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 409979.85 | nM | - |
| CHEMBL409 | BICALUTAMIDE | IC50 | = | 145602.6 | nM | - |
| CHEMBL472004 | — | IC50 | = | 317111.04 | nM | - |
| CHEMBL255342 | — | IC50 | = | 541842.3 | nM | - |
| CHEMBL1186585 | — | IC50 | = | 138015.64 | nM | - |
| CHEMBL1023 | BEXAROTENE | IC50 | = | 1560638.01 | nM | - |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 417742.41 | nM | - |
| CHEMBL2363137 | — | IC50 | = | 336218.08 | nM | - |