Assay Detail
Functional
CHEMBL2363420
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SANGER: Inhibition of human MFH-ino cell growth in a cell viability assay.
110
Total Activities
109
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MFH-ino |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 110 | 5.92 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.35 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.05 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.88 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.78 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 8.58 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.57 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.40 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.25 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 8.01 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.89 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.57 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.55 |
| CHEMBL514499 | GW843682X | — | 1 | 7.45 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.33 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.30 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.15 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 7.15 |
| CHEMBL300389 | — | — | 1 | 7.09 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.07 |
| CHEMBL64925 | MG-132 | — | 2 | 6.95 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.76 |
| CHEMBL379300 | A-443654 | — | 1 | 6.63 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.63 |
| CHEMBL213100 | — | — | 1 | 6.62 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.61 |
| CHEMBL509032 | TAE-684 | — | 1 | 6.49 |
| CHEMBL401930 | — | — | 1 | 6.46 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.44 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 6.33 |
| CHEMBL2363137 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.4432 | nM | 9.35 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.8849 | nM | 9.05 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 1.323 | nM | 8.88 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 1.656 | nM | 8.78 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 2.646 | nM | 8.58 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.68 | nM | 8.57 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 3.987 | nM | 8.40 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 5.596 | nM | 8.25 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 9.895 | nM | 8.01 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 12.93 | nM | 7.89 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 27.08 | nM | 7.57 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 28.12 | nM | 7.55 |
| CHEMBL514499 | GW843682X | IC50 | = | 35.53 | nM | 7.45 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 47.24 | nM | 7.33 |
| CHEMBL513909 | BI-2536 | IC50 | = | 50.03 | nM | 7.30 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 70.61 | nM | 7.15 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 71.49 | nM | 7.15 |
| CHEMBL300389 | — | IC50 | = | 80.68 | nM | 7.09 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 85.01 | nM | 7.07 |
| CHEMBL64925 | MG-132 | IC50 | = | 111.1 | nM | 6.95 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 174.55 | nM | 6.76 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 235.84 | nM | 6.63 |
| CHEMBL379300 | A-443654 | IC50 | = | 235.53 | nM | 6.63 |
| CHEMBL213100 | — | IC50 | = | 239.25 | nM | 6.62 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 246.92 | nM | 6.61 |
| CHEMBL509032 | TAE-684 | IC50 | = | 325.23 | nM | 6.49 |
| CHEMBL401930 | — | IC50 | = | 343.61 | nM | 6.46 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 365.73 | nM | 6.44 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 471.28 | nM | 6.33 |
| CHEMBL2363137 | — | IC50 | = | 505.72 | nM | 6.30 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 523.51 | nM | 6.28 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 588.37 | nM | 6.23 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 643.83 | nM | 6.19 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 751.3 | nM | 6.12 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 814.5 | nM | 6.09 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 863.85 | nM | 6.06 |
| CHEMBL585951 | — | IC50 | = | 1037.45 | nM | 5.98 |
| CHEMBL197603 | — | IC50 | = | 1155.06 | nM | 5.94 |
| CHEMBL64925 | MG-132 | IC50 | = | 1175.01 | nM | 5.93 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 1778.7 | nM | 5.75 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 1986.59 | nM | 5.70 |
| CHEMBL259181 | — | IC50 | = | 2410.91 | nM | 5.62 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 2921.85 | nM | 5.53 |
| CHEMBL803 | CYTARABINE | IC50 | = | 2956.0 | nM | 5.53 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 3465.89 | nM | 5.46 |
| CHEMBL209148 | — | IC50 | = | 3589.17 | nM | 5.45 |
| CHEMBL221137 | EMBELIN | IC50 | = | 5584.14 | nM | 5.25 |
| CHEMBL1023 | BEXAROTENE | IC50 | = | 7213.2 | nM | 5.14 |
| CHEMBL1673039 | — | IC50 | = | 8006.66 | nM | 5.10 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 8583.67 | nM | 5.07 |