Assay Detail
Functional
CHEMBL2363429
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SANGER: Inhibition of human MKN28 cell growth in a cell viability assay.
96
Total Activities
95
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-28 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 96 | 5.52 | 9.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.34 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 8.97 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.57 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.50 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.32 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.01 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.85 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.52 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.50 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.29 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.75 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.64 |
| CHEMBL585951 | — | — | 1 | 6.52 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.21 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.18 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.17 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.04 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.01 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 5.96 |
| CHEMBL217354 | — | — | 1 | 5.95 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 5.94 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.92 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.90 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.88 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.84 |
| CHEMBL259181 | — | — | 1 | 5.76 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.62 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.59 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.59 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.4616 | nM | 9.34 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 1.08 | nM | 8.97 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 2.698 | nM | 8.57 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.172 | nM | 8.50 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 4.771 | nM | 8.32 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 9.79 | nM | 8.01 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 13.98 | nM | 7.85 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 30.12 | nM | 7.52 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 31.91 | nM | 7.50 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 51.21 | nM | 7.29 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 176.53 | nM | 6.75 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 230.09 | nM | 6.64 |
| CHEMBL585951 | — | IC50 | = | 300.66 | nM | 6.52 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 616.87 | nM | 6.21 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 666.24 | nM | 6.18 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 681.41 | nM | 6.17 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 917.37 | nM | 6.04 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 979.96 | nM | 6.01 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 1090.24 | nM | 5.96 |
| CHEMBL217354 | — | IC50 | = | 1132.09 | nM | 5.95 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 1151.24 | nM | 5.94 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1198.16 | nM | 5.92 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1256.36 | nM | 5.90 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1333.91 | nM | 5.88 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1437.89 | nM | 5.84 |
| CHEMBL259181 | — | IC50 | = | 1727.39 | nM | 5.76 |
| CHEMBL803 | CYTARABINE | IC50 | = | 2419.27 | nM | 5.62 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2590.37 | nM | 5.59 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2546.69 | nM | 5.59 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 2692.93 | nM | 5.57 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 3034.63 | nM | 5.52 |
| CHEMBL135561 | — | IC50 | = | 3791.5 | nM | 5.42 |
| CHEMBL2363137 | — | IC50 | = | 4369.51 | nM | 5.36 |
| CHEMBL1190711 | — | IC50 | = | 4493.26 | nM | 5.35 |
| CHEMBL3349342 | — | IC50 | = | 7524.53 | nM | 5.12 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 7763.72 | nM | 5.11 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 8115.15 | nM | 5.09 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 8245.98 | nM | 5.08 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 8629.87 | nM | 5.06 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 8885.16 | nM | 5.05 |
| CHEMBL221137 | EMBELIN | IC50 | = | 10012.51 | nM | 5.00 |
| CHEMBL105442 | CI-1040 | IC50 | = | 10518.04 | nM | 4.98 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 11737.63 | nM | 4.93 |
| CHEMBL258844 | — | IC50 | = | 12631.92 | nM | 4.90 |
| CHEMBL191384 | — | IC50 | = | 14734.17 | nM | 4.83 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 15547.91 | nM | 4.81 |
| CHEMBL472940 | — | IC50 | = | 17256.76 | nM | 4.76 |
| CHEMBL472004 | — | IC50 | = | 17397.32 | nM | 4.76 |
| CHEMBL379975 | — | IC50 | = | 18113.22 | nM | 4.74 |
| CHEMBL591429 | PAC-1 | IC50 | = | 18621.41 | nM | 4.73 |