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Assay Detail

CHEMBL2363432

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Functional
SANGER: Inhibition of human ML-2 cell growth in a cell viability assay.
ChEMBL ↗
126
Total Activities
125
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type ML-2
Confidence 1 — Organism
Curated By Autocuration

Target

ML-2 (CHEMBL614356) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 126 6.03 9.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL325041 BORTEZOMIB 3.0 1 9.09
CHEMBL65 CAMPTOTHECIN -1.0 1 8.66
CHEMBL94657 PATUPILONE 3.0 1 8.61
CHEMBL553025 VINORELBINE 4.0 1 8.36
CHEMBL34259 METHOTREXATE 4.0 1 8.30
CHEMBL105 MITOMYCIN 4.0 1 8.06
CHEMBL159 VINBLASTINE 4.0 1 8.06
CHEMBL3545252 DOCETAXEL 4.0 1 7.99
CHEMBL289228 TIPIFARNIB 3.0 1 7.87
CHEMBL449158 BRYOSTATIN 1 2.0 1 7.86
CHEMBL443684 NAVITOCLAX 3.0 1 7.70
CHEMBL428647 PACLITAXEL 4.0 1 7.69
CHEMBL888 GEMCITABINE 4.0 1 7.59
CHEMBL575448 BMS-754807 2.0 1 7.43
CHEMBL252164 LUMINESPIB 2.0 1 7.43
CHEMBL512504 — — 1 7.36
CHEMBL514499 GW843682X — 1 7.30
CHEMBL513909 BI-2536 2.0 1 7.27
CHEMBL96926 THAPSIGARGIN — 1 7.27
CHEMBL1879463 DACTOLISIB 3.0 1 7.22
CHEMBL64925 MG-132 — 2 6.93
CHEMBL2041933 AZD-7762 1.0 1 6.90
CHEMBL6067492 BLEOMYCIN 4.0 1 6.88
CHEMBL53463 DOXORUBICIN 4.0 1 6.87
CHEMBL1256459 TORIN1 — 1 6.86
CHEMBL507361 MIRDAMETINIB 2.0 1 6.83
CHEMBL1091644 LINSITINIB 3.0 1 6.80
CHEMBL44657 ETOPOSIDE 4.0 1 6.75
CHEMBL401930 — — 1 6.72
CHEMBL379300 A-443654 — 1 6.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL325041 BORTEZOMIB IC50 = 0.8206 nM 9.09
CHEMBL65 CAMPTOTHECIN IC50 = 2.165 nM 8.66
CHEMBL94657 PATUPILONE IC50 = 2.463 nM 8.61
CHEMBL553025 VINORELBINE IC50 = 4.323 nM 8.36
CHEMBL34259 METHOTREXATE IC50 = 4.967 nM 8.30
CHEMBL105 MITOMYCIN IC50 = 8.781 nM 8.06
CHEMBL159 VINBLASTINE IC50 = 8.652 nM 8.06
CHEMBL3545252 DOCETAXEL IC50 = 10.29 nM 7.99
CHEMBL289228 TIPIFARNIB IC50 = 13.64 nM 7.87
CHEMBL449158 BRYOSTATIN 1 IC50 = 13.84 nM 7.86
CHEMBL443684 NAVITOCLAX IC50 = 19.83 nM 7.70
CHEMBL428647 PACLITAXEL IC50 = 20.47 nM 7.69
CHEMBL888 GEMCITABINE IC50 = 25.74 nM 7.59
CHEMBL252164 LUMINESPIB IC50 = 36.71 nM 7.43
CHEMBL575448 BMS-754807 IC50 = 36.95 nM 7.43
CHEMBL512504 — IC50 = 43.44 nM 7.36
CHEMBL514499 GW843682X IC50 = 50.34 nM 7.30
CHEMBL96926 THAPSIGARGIN IC50 = 53.9 nM 7.27
CHEMBL513909 BI-2536 IC50 = 54.14 nM 7.27
CHEMBL1879463 DACTOLISIB IC50 = 60.62 nM 7.22
CHEMBL64925 MG-132 IC50 = 118.06 nM 6.93
CHEMBL2041933 AZD-7762 IC50 = 124.84 nM 6.90
CHEMBL6067492 BLEOMYCIN IC50 = 131.66 nM 6.88
CHEMBL53463 DOXORUBICIN IC50 = 135.16 nM 6.87
CHEMBL1256459 TORIN1 IC50 = 139.53 nM 6.86
CHEMBL507361 MIRDAMETINIB IC50 = 146.12 nM 6.83
CHEMBL1091644 LINSITINIB IC50 = 158.96 nM 6.80
CHEMBL44657 ETOPOSIDE IC50 = 178.47 nM 6.75
CHEMBL401930 — IC50 = 192.21 nM 6.72
CHEMBL379300 A-443654 IC50 = 192.41 nM 6.72
CHEMBL603469 LESTAURTINIB IC50 = 195.17 nM 6.71
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 228.89 nM 6.64
CHEMBL1090090 VX-702 IC50 = 226.61 nM 6.64
CHEMBL109480 TANESPIMYCIN IC50 = 231.19 nM 6.64
CHEMBL1173655 AFATINIB IC50 = 248.02 nM 6.61
CHEMBL300389 — IC50 = 269.44 nM 6.57
CHEMBL803 CYTARABINE IC50 = 269.65 nM 6.57
CHEMBL1614701 SELUMETINIB IC50 = 293.63 nM 6.53
CHEMBL2144069 — IC50 = 368.86 nM 6.43
CHEMBL64925 MG-132 IC50 = 473.49 nM 6.33
CHEMBL509032 TAE-684 IC50 = 490.31 nM 6.31
CHEMBL3349342 — IC50 = 503.01 nM 6.30
CHEMBL1801204 AZD-8055 IC50 = 584.78 nM 6.23
CHEMBL9470 SHIKONIN IC50 = 617.74 nM 6.21
CHEMBL585951 — IC50 = 702.12 nM 6.15
CHEMBL608533 MIDOSTAURIN IC50 = 798.59 nM 6.10
CHEMBL573107 — IC50 = 855.75 nM 6.07
CHEMBL572878 TOZASERTIB IC50 = 902.59 nM 6.04
CHEMBL98 VORINOSTAT IC50 = 1004.07 nM 6.00
CHEMBL1171837 PONATINIB IC50 = 997.5 nM 6.00