Assay Detail
Functional
CHEMBL2363433
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SANGER: Inhibition of human MLMA cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MLMA |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.61 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 8.48 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.45 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.33 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.09 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.05 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.87 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.85 |
| CHEMBL514499 | GW843682X | — | 1 | 7.60 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 7.54 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.43 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.34 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 7.26 |
| CHEMBL300389 | — | — | 1 | 7.24 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.24 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.17 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.13 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.12 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 7.04 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.01 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.91 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.87 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 6.85 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.85 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.83 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.80 |
| CHEMBL217354 | — | — | 1 | 6.73 |
| CHEMBL197603 | — | — | 1 | 6.68 |
| CHEMBL512504 | — | — | 1 | 6.63 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.57 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 3.313 | nM | 8.48 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.551 | nM | 8.45 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 4.652 | nM | 8.33 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 8.145 | nM | 8.09 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 8.854 | nM | 8.05 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 13.58 | nM | 7.87 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 14.06 | nM | 7.85 |
| CHEMBL514499 | GW843682X | IC50 | = | 24.93 | nM | 7.60 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 28.49 | nM | 7.54 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 36.9 | nM | 7.43 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 46.09 | nM | 7.34 |
| CHEMBL803 | CYTARABINE | IC50 | = | 55.51 | nM | 7.26 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 57.51 | nM | 7.24 |
| CHEMBL300389 | — | IC50 | = | 57.43 | nM | 7.24 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 67.8 | nM | 7.17 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 74.65 | nM | 7.13 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 75.34 | nM | 7.12 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 90.6 | nM | 7.04 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 96.54 | nM | 7.01 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 122.08 | nM | 6.91 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 136.58 | nM | 6.87 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 140.32 | nM | 6.85 |
| CHEMBL513909 | BI-2536 | IC50 | = | 141.67 | nM | 6.85 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 146.24 | nM | 6.83 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 159.88 | nM | 6.80 |
| CHEMBL217354 | — | IC50 | = | 185.1 | nM | 6.73 |
| CHEMBL197603 | — | IC50 | = | 208.61 | nM | 6.68 |
| CHEMBL512504 | — | IC50 | = | 233.99 | nM | 6.63 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 271.56 | nM | 6.57 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 293.39 | nM | 6.53 |
| CHEMBL379300 | A-443654 | IC50 | = | 447.01 | nM | 6.35 |
| CHEMBL585951 | — | IC50 | = | 484.34 | nM | 6.32 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 539.08 | nM | 6.27 |
| CHEMBL379975 | — | IC50 | = | 541.37 | nM | 6.27 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 870.48 | nM | 6.06 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 906.75 | nM | 6.04 |
| CHEMBL1190711 | — | IC50 | = | 993.18 | nM | 6.00 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1309.78 | nM | 5.88 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 1324.07 | nM | 5.88 |
| CHEMBL213100 | — | IC50 | = | 1923.1 | nM | 5.72 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1882.34 | nM | 5.72 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 1966.77 | nM | 5.71 |
| CHEMBL401930 | — | IC50 | = | 2005.39 | nM | 5.70 |
| CHEMBL64925 | MG-132 | IC50 | = | 2185.76 | nM | 5.66 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 2287.03 | nM | 5.64 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 2688.56 | nM | 5.57 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 2701.22 | nM | 5.57 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2967.17 | nM | 5.53 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 3381.91 | nM | 5.47 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 3722.58 | nM | 5.43 |