Assay Detail
Functional
CHEMBL2363434
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SANGER: Inhibition of human MMAC-SF cell growth in a cell viability assay.
130
Total Activities
128
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MMAC-SF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.41 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.66 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.23 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.82 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.69 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.64 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.58 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.55 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.42 |
| CHEMBL2144069 | — | — | 1 | 7.40 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.37 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.34 |
| CHEMBL64925 | MG-132 | — | 2 | 7.14 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.14 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.12 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.07 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.98 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.97 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 6.96 |
| CHEMBL300389 | — | — | 1 | 6.45 |
| CHEMBL401930 | — | — | 1 | 6.30 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.30 |
| CHEMBL514499 | GW843682X | — | 1 | 6.29 |
| CHEMBL1230020 | PLX-4720 | — | 1 | 6.16 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.12 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.00 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.00 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.86 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 5.75 |
| CHEMBL585951 | — | — | 1 | 5.61 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.2163 | nM | 9.66 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 5.858 | nM | 8.23 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 15.09 | nM | 7.82 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 20.46 | nM | 7.69 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 23.04 | nM | 7.64 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 26.33 | nM | 7.58 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 28.26 | nM | 7.55 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 38.4 | nM | 7.42 |
| CHEMBL2144069 | — | IC50 | = | 40.07 | nM | 7.40 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 42.97 | nM | 7.37 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 45.34 | nM | 7.34 |
| CHEMBL64925 | MG-132 | IC50 | = | 72.68 | nM | 7.14 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 72.1 | nM | 7.14 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 76.68 | nM | 7.12 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 84.29 | nM | 7.07 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 105.31 | nM | 6.98 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 106.48 | nM | 6.97 |
| CHEMBL105442 | CI-1040 | IC50 | = | 109.74 | nM | 6.96 |
| CHEMBL300389 | — | IC50 | = | 353.7 | nM | 6.45 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 501.17 | nM | 6.30 |
| CHEMBL401930 | — | IC50 | = | 500.4 | nM | 6.30 |
| CHEMBL514499 | GW843682X | IC50 | = | 515.73 | nM | 6.29 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 686.14 | nM | 6.16 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 751.96 | nM | 6.12 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1011.63 | nM | 6.00 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 1004.39 | nM | 6.00 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1395.95 | nM | 5.86 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 1776.6 | nM | 5.75 |
| CHEMBL585951 | — | IC50 | = | 2477.05 | nM | 5.61 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 2686.89 | nM | 5.57 |
| CHEMBL513909 | BI-2536 | IC50 | = | 2866.28 | nM | 5.54 |
| CHEMBL217354 | — | IC50 | = | 3143.89 | nM | 5.50 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 3169.7 | nM | 5.50 |
| CHEMBL64925 | MG-132 | IC50 | = | 3210.82 | nM | 5.49 |
| CHEMBL2363137 | — | IC50 | = | 3917.24 | nM | 5.41 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 4024.67 | nM | 5.39 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 4058.47 | nM | 5.39 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4268.59 | nM | 5.37 |
| CHEMBL379300 | A-443654 | IC50 | = | 5203.56 | nM | 5.28 |
| CHEMBL515416 | — | IC50 | = | 6035.31 | nM | 5.22 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 6185.56 | nM | 5.21 |
| CHEMBL535 | SUNITINIB | IC50 | = | 6109.49 | nM | 5.21 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 6875.53 | nM | 5.16 |
| CHEMBL509032 | TAE-684 | IC50 | = | 7064.92 | nM | 5.15 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 7116.07 | nM | 5.15 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 8793.07 | nM | 5.06 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 9097.51 | nM | 5.04 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 9687.5 | nM | 5.01 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 9979.04 | nM | 5.00 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 10396.11 | nM | 4.98 |