Assay Detail
Functional
CHEMBL2363437
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human MOLT-16 cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.84 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 9.14 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.62 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.54 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.47 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.34 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.34 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.08 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.94 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.89 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.89 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.79 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.77 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.75 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.67 |
| CHEMBL514499 | GW843682X | — | 1 | 7.50 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 7.44 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.37 |
| CHEMBL512504 | — | — | 1 | 7.21 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.09 |
| CHEMBL379300 | A-443654 | — | 1 | 7.08 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 7.05 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.05 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.59 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 6.59 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.54 |
| CHEMBL64925 | MG-132 | — | 2 | 6.53 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 6.52 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.39 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.29 |
| CHEMBL1190711 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.7318 | nM | 9.14 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 2.429 | nM | 8.62 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 2.893 | nM | 8.54 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 3.413 | nM | 8.47 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 4.527 | nM | 8.34 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 4.524 | nM | 8.34 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 8.269 | nM | 8.08 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 12.84 | nM | 7.89 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 12.78 | nM | 7.89 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 16.22 | nM | 7.79 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 17.15 | nM | 7.77 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 17.88 | nM | 7.75 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 21.53 | nM | 7.67 |
| CHEMBL514499 | GW843682X | IC50 | = | 31.48 | nM | 7.50 |
| CHEMBL803 | CYTARABINE | IC50 | = | 36.07 | nM | 7.44 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 43.05 | nM | 7.37 |
| CHEMBL512504 | — | IC50 | = | 61.91 | nM | 7.21 |
| CHEMBL513909 | BI-2536 | IC50 | = | 81.21 | nM | 7.09 |
| CHEMBL379300 | A-443654 | IC50 | = | 83.71 | nM | 7.08 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 89.78 | nM | 7.05 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 88.07 | nM | 7.05 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 258.49 | nM | 6.59 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 258.23 | nM | 6.59 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 290.5 | nM | 6.54 |
| CHEMBL64925 | MG-132 | IC50 | = | 295.24 | nM | 6.53 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 303.2 | nM | 6.52 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 410.17 | nM | 6.39 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 518.08 | nM | 6.29 |
| CHEMBL1190711 | — | IC50 | = | 570.77 | nM | 6.24 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 585.19 | nM | 6.23 |
| CHEMBL202721 | — | IC50 | = | 609.61 | nM | 6.21 |
| CHEMBL535 | SUNITINIB | IC50 | = | 631.32 | nM | 6.20 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 647.93 | nM | 6.19 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 652.64 | nM | 6.18 |
| CHEMBL585951 | — | IC50 | = | 733.39 | nM | 6.13 |
| CHEMBL509032 | TAE-684 | IC50 | = | 875.89 | nM | 6.06 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 938.45 | nM | 6.03 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1297.97 | nM | 5.89 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 1354.05 | nM | 5.87 |
| CHEMBL191384 | — | IC50 | = | 1384.53 | nM | 5.86 |
| CHEMBL379975 | — | IC50 | = | 1424.36 | nM | 5.85 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1677.65 | nM | 5.78 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1733.07 | nM | 5.76 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 1786.04 | nM | 5.75 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1889.25 | nM | 5.72 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 1955.75 | nM | 5.71 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 1929.25 | nM | 5.71 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 2070.58 | nM | 5.68 |
| CHEMBL1673039 | — | IC50 | = | 2710.24 | nM | 5.57 |