Assay Detail
Functional
CHEMBL2363441
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SANGER: Inhibition of human MRK-nu-1 cell growth in a cell viability assay.
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MRK-nu-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 5.88 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.05 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.59 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.52 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.35 |
| CHEMBL1256459 | TORIN1 | — | 1 | 8.15 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.64 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.63 |
| CHEMBL514499 | GW843682X | — | 1 | 7.52 |
| CHEMBL300389 | — | — | 1 | 7.43 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.36 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.31 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.21 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.99 |
| CHEMBL379300 | A-443654 | — | 1 | 6.98 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.96 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.93 |
| CHEMBL512504 | — | — | 1 | 6.75 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.47 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.42 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.38 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.37 |
| CHEMBL585951 | — | — | 1 | 6.26 |
| CHEMBL220241 | GSK-269962A | — | 1 | 6.24 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.19 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 6.12 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.95 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.84 |
| CHEMBL4298697 | — | — | 1 | 5.70 |
| CHEMBL450786 | PHA-665752 | — | 1 | 5.62 |
| CHEMBL515416 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.9001 | nM | 9.05 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 2.567 | nM | 8.59 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.99 | nM | 8.52 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 4.474 | nM | 8.35 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 7.074 | nM | 8.15 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 23.22 | nM | 7.63 |
| CHEMBL514499 | GW843682X | IC50 | = | 30.08 | nM | 7.52 |
| CHEMBL300389 | — | IC50 | = | 37.31 | nM | 7.43 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 43.66 | nM | 7.36 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 49.36 | nM | 7.31 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 61.82 | nM | 7.21 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 101.93 | nM | 6.99 |
| CHEMBL379300 | A-443654 | IC50 | = | 103.74 | nM | 6.98 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 110.25 | nM | 6.96 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 116.2 | nM | 6.93 |
| CHEMBL512504 | — | IC50 | = | 177.51 | nM | 6.75 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 339.6 | nM | 6.47 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 381.3 | nM | 6.42 |
| CHEMBL513909 | BI-2536 | IC50 | = | 422.05 | nM | 6.38 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 431.53 | nM | 6.37 |
| CHEMBL585951 | — | IC50 | = | 545.4 | nM | 6.26 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 575.72 | nM | 6.24 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 645.91 | nM | 6.19 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 760.2 | nM | 6.12 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1117.62 | nM | 5.95 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 1452.52 | nM | 5.84 |
| CHEMBL4298697 | — | IC50 | = | 2011.02 | nM | 5.70 |
| CHEMBL450786 | PHA-665752 | IC50 | = | 2400.56 | nM | 5.62 |
| CHEMBL515416 | — | IC50 | = | 2521.63 | nM | 5.60 |
| CHEMBL2363137 | — | IC50 | = | 2731.09 | nM | 5.56 |
| CHEMBL1190711 | — | IC50 | = | 2907.45 | nM | 5.54 |
| CHEMBL197603 | — | IC50 | = | 2953.29 | nM | 5.53 |
| CHEMBL1242367 | — | IC50 | = | 3085.49 | nM | 5.51 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 3614.68 | nM | 5.44 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 3707.35 | nM | 5.43 |
| CHEMBL213100 | — | IC50 | = | 4717.92 | nM | 5.33 |
| CHEMBL509032 | TAE-684 | IC50 | = | 5436.33 | nM | 5.26 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 7053.64 | nM | 5.15 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 7129.69 | nM | 5.15 |
| CHEMBL180127 | SALUBRINAL | IC50 | = | 7751.71 | nM | 5.11 |
| CHEMBL591429 | PAC-1 | IC50 | = | 8189.17 | nM | 5.09 |
| CHEMBL209148 | — | IC50 | = | 8300.22 | nM | 5.08 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 8363.04 | nM | 5.08 |
| CHEMBL1673039 | — | IC50 | = | 12212.73 | nM | 4.91 |
| CHEMBL221137 | EMBELIN | IC50 | = | 12905.98 | nM | 4.89 |
| CHEMBL64925 | MG-132 | IC50 | = | 13194.97 | nM | 4.88 |
| CHEMBL554 | LAPATINIB | IC50 | = | 20912.98 | nM | 4.68 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 22907.4 | nM | 4.64 |
| CHEMBL401930 | — | IC50 | = | 22903.46 | nM | 4.64 |