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Assay Detail

CHEMBL2363450

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Functional
SANGER: Inhibition of human NALM-6 cell growth in a cell viability assay.
ChEMBL ↗
77
Total Activities
76
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NALM-6
Confidence 1 — Organism
Curated By Autocuration

Target

NALM-6 (CHEMBL614187) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 77 6.20 10.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL888 GEMCITABINE 4.0 1 10.21
CHEMBL96926 THAPSIGARGIN — 1 9.95
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 9.45
CHEMBL252164 LUMINESPIB 2.0 1 9.07
CHEMBL105 MITOMYCIN 4.0 1 8.97
CHEMBL94657 PATUPILONE 3.0 1 8.66
CHEMBL9470 SHIKONIN — 1 8.55
CHEMBL325041 BORTEZOMIB 3.0 1 8.35
CHEMBL553025 VINORELBINE 4.0 1 8.23
CHEMBL1256459 TORIN1 — 1 7.96
CHEMBL428647 PACLITAXEL 4.0 1 7.92
CHEMBL53463 DOXORUBICIN 4.0 1 7.73
CHEMBL514499 GW843682X — 1 7.61
CHEMBL572878 TOZASERTIB 2.0 1 7.59
CHEMBL512504 — — 1 7.50
CHEMBL289228 TIPIFARNIB 3.0 1 7.44
CHEMBL300389 — — 1 7.33
CHEMBL513909 BI-2536 2.0 1 7.22
CHEMBL608533 MIDOSTAURIN 4.0 1 6.97
CHEMBL379300 A-443654 — 1 6.89
CHEMBL5416410 DASATINIB 4.0 1 6.71
CHEMBL44657 ETOPOSIDE 4.0 1 6.69
CHEMBL585951 — — 1 6.67
CHEMBL1171837 PONATINIB 4.0 1 6.59
CHEMBL1190711 — — 1 6.38
CHEMBL6067492 BLEOMYCIN 4.0 1 6.38
CHEMBL27759 ENTINOSTAT 3.0 1 6.19
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.17
CHEMBL392695 S-TRITYL-L-CYSTEINE — 1 6.17
CHEMBL2165191 AZD-6482 2.0 1 6.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL888 GEMCITABINE IC50 = 0.06223 nM 10.21
CHEMBL96926 THAPSIGARGIN IC50 = 0.1121 nM 9.95
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 0.3556 nM 9.45
CHEMBL252164 LUMINESPIB IC50 = 0.8423 nM 9.07
CHEMBL105 MITOMYCIN IC50 = 1.066 nM 8.97
CHEMBL94657 PATUPILONE IC50 = 2.178 nM 8.66
CHEMBL9470 SHIKONIN IC50 = 2.797 nM 8.55
CHEMBL325041 BORTEZOMIB IC50 = 4.494 nM 8.35
CHEMBL553025 VINORELBINE IC50 = 5.94 nM 8.23
CHEMBL1256459 TORIN1 IC50 = 11.02 nM 7.96
CHEMBL428647 PACLITAXEL IC50 = 12.14 nM 7.92
CHEMBL53463 DOXORUBICIN IC50 = 18.63 nM 7.73
CHEMBL514499 GW843682X IC50 = 24.54 nM 7.61
CHEMBL572878 TOZASERTIB IC50 = 25.52 nM 7.59
CHEMBL512504 — IC50 = 31.66 nM 7.50
CHEMBL289228 TIPIFARNIB IC50 = 36.21 nM 7.44
CHEMBL300389 — IC50 = 46.75 nM 7.33
CHEMBL513909 BI-2536 IC50 = 59.73 nM 7.22
CHEMBL608533 MIDOSTAURIN IC50 = 108.03 nM 6.97
CHEMBL379300 A-443654 IC50 = 127.98 nM 6.89
CHEMBL5416410 DASATINIB IC50 = 192.95 nM 6.71
CHEMBL44657 ETOPOSIDE IC50 = 205.84 nM 6.69
CHEMBL585951 — IC50 = 214.41 nM 6.67
CHEMBL1171837 PONATINIB IC50 = 255.43 nM 6.59
CHEMBL1190711 — IC50 = 417.39 nM 6.38
CHEMBL6067492 BLEOMYCIN IC50 = 420.16 nM 6.38
CHEMBL27759 ENTINOSTAT IC50 = 648.6 nM 6.19
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 676.46 nM 6.17
CHEMBL449158 BRYOSTATIN 1 IC50 = 672.44 nM 6.17
CHEMBL591429 PAC-1 IC50 = 703.06 nM 6.15
CHEMBL2165191 AZD-6482 IC50 = 704.65 nM 6.15
CHEMBL509032 TAE-684 IC50 = 907.39 nM 6.04
CHEMBL472940 — IC50 = 976.94 nM 6.01
CHEMBL220241 GSK-269962A IC50 = 1561.09 nM 5.81
CHEMBL258844 — IC50 = 2147.14 nM 5.67
CHEMBL197603 — IC50 = 2243.36 nM 5.65
CHEMBL535 SUNITINIB IC50 = 2904.73 nM 5.54
CHEMBL401930 — IC50 = 2966.36 nM 5.53
CHEMBL413 SIROLIMUS IC50 = 3009.33 nM 5.52
CHEMBL259181 — IC50 = 3505.56 nM 5.46
CHEMBL191384 — IC50 = 4493.73 nM 5.35
CHEMBL64925 MG-132 IC50 = 4925.82 nM 5.31
CHEMBL1673039 — IC50 = 4956.37 nM 5.30
CHEMBL1242367 — IC50 = 4984.63 nM 5.30
CHEMBL1091644 LINSITINIB IC50 = 6332.3 nM 5.20
CHEMBL2363137 — IC50 = 6281.7 nM 5.20
CHEMBL601719 CRIZOTINIB IC50 = 6683.87 nM 5.17
CHEMBL64925 MG-132 IC50 = 6867.54 nM 5.16
CHEMBL575448 BMS-754807 IC50 = 7121.63 nM 5.15
CHEMBL221137 EMBELIN IC50 = 9089.79 nM 5.04