Assay Detail
Functional
CHEMBL2363451
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human NB1 cell growth in a cell viability assay.
77
Total Activities
76
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NB1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 77 | 5.70 | 8.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509032 | TAE-684 | — | 1 | 8.79 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.16 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.84 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.58 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.57 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.57 |
| CHEMBL514499 | GW843682X | — | 1 | 7.45 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.34 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.18 |
| CHEMBL300389 | — | — | 1 | 7.07 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 7.04 |
| CHEMBL379300 | A-443654 | — | 1 | 6.93 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.84 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.73 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.55 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.55 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.42 |
| CHEMBL585951 | — | — | 1 | 6.35 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.31 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.14 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.14 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.99 |
| CHEMBL512504 | — | — | 1 | 5.95 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.89 |
| CHEMBL1190711 | — | — | 1 | 5.77 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.71 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 5.53 |
| CHEMBL220241 | GSK-269962A | — | 1 | 5.42 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 5.39 |
| CHEMBL64925 | MG-132 | — | 2 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509032 | TAE-684 | IC50 | = | 1.62 | nM | 8.79 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 6.876 | nM | 8.16 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 14.59 | nM | 7.84 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 26.08 | nM | 7.58 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 26.87 | nM | 7.57 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 27.12 | nM | 7.57 |
| CHEMBL514499 | GW843682X | IC50 | = | 35.12 | nM | 7.45 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 45.99 | nM | 7.34 |
| CHEMBL513909 | BI-2536 | IC50 | = | 66.13 | nM | 7.18 |
| CHEMBL300389 | — | IC50 | = | 84.33 | nM | 7.07 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 91.98 | nM | 7.04 |
| CHEMBL379300 | A-443654 | IC50 | = | 117.48 | nM | 6.93 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 144.26 | nM | 6.84 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 186.61 | nM | 6.73 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 278.76 | nM | 6.55 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 279.26 | nM | 6.55 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 384.45 | nM | 6.42 |
| CHEMBL585951 | — | IC50 | = | 447.03 | nM | 6.35 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 487.53 | nM | 6.31 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 731.21 | nM | 6.14 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 718.21 | nM | 6.14 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1034.34 | nM | 5.99 |
| CHEMBL512504 | — | IC50 | = | 1112.41 | nM | 5.95 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1277.32 | nM | 5.89 |
| CHEMBL1190711 | — | IC50 | = | 1712.17 | nM | 5.77 |
| CHEMBL535 | SUNITINIB | IC50 | = | 1961.17 | nM | 5.71 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 2944.37 | nM | 5.53 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 3843.69 | nM | 5.42 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 4066.44 | nM | 5.39 |
| CHEMBL64925 | MG-132 | IC50 | = | 4841.3 | nM | 5.32 |
| CHEMBL515416 | — | IC50 | = | 5575.24 | nM | 5.25 |
| CHEMBL1242367 | — | IC50 | = | 5885.15 | nM | 5.23 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 7404.07 | nM | 5.13 |
| CHEMBL2363137 | — | IC50 | = | 8380.52 | nM | 5.08 |
| CHEMBL191384 | — | IC50 | = | 9372.85 | nM | 5.03 |
| CHEMBL259181 | — | IC50 | = | 9304.99 | nM | 5.03 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 10207.71 | nM | 4.99 |
| CHEMBL2144069 | — | IC50 | = | 10573.13 | nM | 4.98 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 11024.19 | nM | 4.96 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 11596.47 | nM | 4.94 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 12330.75 | nM | 4.91 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 12290.01 | nM | 4.91 |
| CHEMBL591429 | PAC-1 | IC50 | = | 12411.57 | nM | 4.91 |
| CHEMBL1673039 | — | IC50 | = | 13050.86 | nM | 4.88 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 14193.51 | nM | 4.85 |
| CHEMBL401930 | — | IC50 | = | 15840.36 | nM | 4.80 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 16727.38 | nM | 4.78 |
| CHEMBL180127 | SALUBRINAL | IC50 | = | 17229.47 | nM | 4.76 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 17318.82 | nM | 4.76 |
| CHEMBL483847 | — | IC50 | = | 19312.16 | nM | 4.71 |