Assay Detail
Functional
CHEMBL2363462
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SANGER: Inhibition of human NCCIT cell growth in a cell viability assay.
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCCIT |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 5.68 | 10.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 10.71 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.76 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.27 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.75 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.74 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.70 |
| CHEMBL300389 | — | — | 1 | 7.32 |
| CHEMBL514499 | GW843682X | — | 1 | 7.22 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.18 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.86 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.75 |
| CHEMBL379300 | A-443654 | — | 1 | 6.63 |
| CHEMBL64925 | MG-132 | — | 2 | 6.50 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.41 |
| CHEMBL585951 | — | — | 1 | 6.40 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.29 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.26 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.21 |
| CHEMBL217092 | SARACATINIB | 3.0 | 1 | 6.13 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.12 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.06 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.00 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.97 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.89 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.86 |
| CHEMBL1190711 | — | — | 1 | 5.63 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 5.62 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 5.59 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.58 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.01961 | nM | 10.71 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.729 | nM | 8.76 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 5.419 | nM | 8.27 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 17.69 | nM | 7.75 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 18.36 | nM | 7.74 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 20.13 | nM | 7.70 |
| CHEMBL300389 | — | IC50 | = | 48.46 | nM | 7.32 |
| CHEMBL514499 | GW843682X | IC50 | = | 59.92 | nM | 7.22 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 66.04 | nM | 7.18 |
| CHEMBL513909 | BI-2536 | IC50 | = | 139.39 | nM | 6.86 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 176.26 | nM | 6.75 |
| CHEMBL379300 | A-443654 | IC50 | = | 234.23 | nM | 6.63 |
| CHEMBL64925 | MG-132 | IC50 | = | 317.83 | nM | 6.50 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 386.49 | nM | 6.41 |
| CHEMBL585951 | — | IC50 | = | 397.64 | nM | 6.40 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 517.16 | nM | 6.29 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 543.21 | nM | 6.26 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 617.15 | nM | 6.21 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 732.18 | nM | 6.13 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 767.75 | nM | 6.12 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 878.41 | nM | 6.06 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1010.24 | nM | 6.00 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 1068.73 | nM | 5.97 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1279.48 | nM | 5.89 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1379.88 | nM | 5.86 |
| CHEMBL1190711 | — | IC50 | = | 2357.61 | nM | 5.63 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 2390.72 | nM | 5.62 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 2572.4 | nM | 5.59 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 2605.43 | nM | 5.58 |
| CHEMBL64925 | MG-132 | IC50 | = | 2677.95 | nM | 5.57 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 2866.16 | nM | 5.54 |
| CHEMBL509032 | TAE-684 | IC50 | = | 3088.62 | nM | 5.51 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 3218.09 | nM | 5.49 |
| CHEMBL401930 | — | IC50 | = | 3828.46 | nM | 5.42 |
| CHEMBL1673039 | — | IC50 | = | 4149.91 | nM | 5.38 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 4384.97 | nM | 5.36 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 5332.29 | nM | 5.27 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 6934.6 | nM | 5.16 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 7554.82 | nM | 5.12 |
| CHEMBL591429 | PAC-1 | IC50 | = | 7973.47 | nM | 5.10 |
| CHEMBL535 | SUNITINIB | IC50 | = | 8717.45 | nM | 5.06 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 9531.69 | nM | 5.02 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 11058.16 | nM | 4.96 |
| CHEMBL1643959 | — | IC50 | = | 11692.18 | nM | 4.93 |
| CHEMBL180127 | SALUBRINAL | IC50 | = | 11603.86 | nM | 4.93 |
| CHEMBL258844 | — | IC50 | = | 12003.87 | nM | 4.92 |
| CHEMBL2363137 | — | IC50 | = | 13376.6 | nM | 4.87 |
| CHEMBL259181 | — | IC50 | = | 14264.04 | nM | 4.85 |
| CHEMBL221137 | EMBELIN | IC50 | = | 19185.08 | nM | 4.72 |
| CHEMBL209148 | — | IC50 | = | 19771.83 | nM | 4.70 |