Assay Detail
Functional
CHEMBL2363469
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SANGER: Inhibition of human NCI-H1355 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1355 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.69 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 9.42 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.05 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.04 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 9.00 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.54 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.26 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.17 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.05 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.04 |
| CHEMBL514499 | GW843682X | — | 1 | 7.92 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 7.85 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.78 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.71 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.62 |
| CHEMBL300389 | — | — | 1 | 7.60 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.55 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.33 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.25 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.18 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.16 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 6.96 |
| CHEMBL379300 | A-443654 | — | 1 | 6.95 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.93 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.91 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.82 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.82 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 6.74 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.55 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.41 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.3806 | nM | 9.42 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.8953 | nM | 9.05 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.9152 | nM | 9.04 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 1.009 | nM | 9.00 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 5.482 | nM | 8.26 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 6.794 | nM | 8.17 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 8.886 | nM | 8.05 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 9.138 | nM | 8.04 |
| CHEMBL514499 | GW843682X | IC50 | = | 11.93 | nM | 7.92 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 14.01 | nM | 7.85 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 16.46 | nM | 7.78 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 19.54 | nM | 7.71 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 24.01 | nM | 7.62 |
| CHEMBL300389 | — | IC50 | = | 24.86 | nM | 7.60 |
| CHEMBL513909 | BI-2536 | IC50 | = | 27.83 | nM | 7.55 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 46.34 | nM | 7.33 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 55.88 | nM | 7.25 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 66.1 | nM | 7.18 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 69.28 | nM | 7.16 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 110.28 | nM | 6.96 |
| CHEMBL379300 | A-443654 | IC50 | = | 113.2 | nM | 6.95 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 116.8 | nM | 6.93 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 124.38 | nM | 6.91 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 152.24 | nM | 6.82 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 152.93 | nM | 6.82 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 181.35 | nM | 6.74 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 280.74 | nM | 6.55 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 389.72 | nM | 6.41 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 538.78 | nM | 6.27 |
| CHEMBL509032 | TAE-684 | IC50 | = | 551.84 | nM | 6.26 |
| CHEMBL401930 | — | IC50 | = | 553.23 | nM | 6.26 |
| CHEMBL803 | CYTARABINE | IC50 | = | 555.54 | nM | 6.25 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 678.52 | nM | 6.17 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 678.16 | nM | 6.17 |
| CHEMBL64925 | MG-132 | IC50 | = | 686.19 | nM | 6.16 |
| CHEMBL585951 | — | IC50 | = | 875.09 | nM | 6.06 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 928.01 | nM | 6.03 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 973.77 | nM | 6.01 |
| CHEMBL191384 | — | IC50 | = | 1109.6 | nM | 5.96 |
| CHEMBL217354 | — | IC50 | = | 1291.58 | nM | 5.89 |
| CHEMBL135561 | — | IC50 | = | 1819.23 | nM | 5.74 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 2117.92 | nM | 5.67 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 2559.51 | nM | 5.59 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 2822.51 | nM | 5.55 |
| CHEMBL2363137 | — | IC50 | = | 2927.36 | nM | 5.53 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3007.96 | nM | 5.52 |
| CHEMBL1190711 | — | IC50 | = | 3490.73 | nM | 5.46 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 3931.45 | nM | 5.41 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 4551.46 | nM | 5.34 |