Assay Detail
Functional
CHEMBL2363473
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SANGER: Inhibition of human NCI-H1437 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1437 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.66 | 9.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.16 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.61 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.59 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.15 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.11 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.03 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.61 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.46 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.46 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.20 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.19 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.09 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.06 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.99 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.98 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.92 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.90 |
| CHEMBL585951 | — | — | 1 | 6.62 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 6.45 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.39 |
| CHEMBL217354 | — | — | 1 | 6.27 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.22 |
| CHEMBL3349342 | — | — | 1 | 6.15 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.13 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.10 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 5.81 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.81 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.78 |
| CHEMBL1190711 | — | — | 1 | 5.75 |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.6893 | nM | 9.16 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 2.465 | nM | 8.61 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 2.602 | nM | 8.59 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 7.111 | nM | 8.15 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 7.76 | nM | 8.11 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 9.418 | nM | 8.03 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 24.6 | nM | 7.61 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 34.93 | nM | 7.46 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 34.49 | nM | 7.46 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 63.28 | nM | 7.20 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 64.64 | nM | 7.19 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 80.5 | nM | 7.09 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 87.66 | nM | 7.06 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 103.2 | nM | 6.99 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 105.34 | nM | 6.98 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 121.57 | nM | 6.92 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 126.26 | nM | 6.90 |
| CHEMBL585951 | — | IC50 | = | 242.77 | nM | 6.62 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 352.85 | nM | 6.45 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 408.05 | nM | 6.39 |
| CHEMBL217354 | — | IC50 | = | 538.34 | nM | 6.27 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 606.19 | nM | 6.22 |
| CHEMBL3349342 | — | IC50 | = | 702.23 | nM | 6.15 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 742.72 | nM | 6.13 |
| CHEMBL803 | CYTARABINE | IC50 | = | 798.06 | nM | 6.10 |
| CHEMBL105442 | CI-1040 | IC50 | = | 1552.75 | nM | 5.81 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1557.48 | nM | 5.81 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1677.36 | nM | 5.78 |
| CHEMBL1190711 | — | IC50 | = | 1796.95 | nM | 5.75 |
| CHEMBL591429 | PAC-1 | IC50 | = | 2229.73 | nM | 5.65 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2418.73 | nM | 5.62 |
| CHEMBL135561 | — | IC50 | = | 2560.64 | nM | 5.59 |
| CHEMBL577784 | BX-795 | IC50 | = | 2769.98 | nM | 5.56 |
| CHEMBL2363137 | — | IC50 | = | 2727.59 | nM | 5.56 |
| CHEMBL258844 | — | IC50 | = | 2793.59 | nM | 5.55 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 2922.57 | nM | 5.53 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 3381.15 | nM | 5.47 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 3559.32 | nM | 5.45 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 4023.02 | nM | 5.39 |
| CHEMBL191384 | — | IC50 | = | 4152.88 | nM | 5.38 |
| CHEMBL573107 | — | IC50 | = | 4929.3 | nM | 5.31 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 5711.16 | nM | 5.24 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 6130.2 | nM | 5.21 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 6240.73 | nM | 5.21 |
| CHEMBL399530 | — | IC50 | = | 6314.21 | nM | 5.20 |
| CHEMBL221137 | EMBELIN | IC50 | = | 6271.43 | nM | 5.20 |
| CHEMBL259181 | — | IC50 | = | 6892.95 | nM | 5.16 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 8211.6 | nM | 5.09 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 8097.95 | nM | 5.09 |
| CHEMBL222102 | KU-55933 | IC50 | = | 9809.7 | nM | 5.01 |