Assay Detail
Functional
CHEMBL2363476
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SANGER: Inhibition of human NCI-H1573 cell growth in a cell viability assay.
85
Total Activities
85
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1573 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 85 | 5.35 | 8.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.79 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 8.63 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.22 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.19 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.51 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.06 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.76 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.75 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.72 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.34 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.16 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.13 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.12 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.04 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.85 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.83 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.79 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.76 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 5.68 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 5.55 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.50 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 5.28 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.23 |
| CHEMBL3349342 | — | — | 1 | 5.22 |
| CHEMBL477772 | PAZOPANIB | 4.0 | 1 | 5.22 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.17 |
| CHEMBL217354 | — | — | 1 | 5.15 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.12 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.04 |
| CHEMBL1190711 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 1.622 | nM | 8.79 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 2.357 | nM | 8.63 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 6.074 | nM | 8.22 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 6.416 | nM | 8.19 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 30.74 | nM | 7.51 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 87.48 | nM | 7.06 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 173.4 | nM | 6.76 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 176.78 | nM | 6.75 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 188.8 | nM | 6.72 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 455.69 | nM | 6.34 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 685.91 | nM | 6.16 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 736.3 | nM | 6.13 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 766.34 | nM | 6.12 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 902.29 | nM | 6.04 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1422.57 | nM | 5.85 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1460.85 | nM | 5.83 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 1636.36 | nM | 5.79 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1717.33 | nM | 5.76 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 2072.98 | nM | 5.68 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 2807.23 | nM | 5.55 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 3196.41 | nM | 5.50 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 5272.38 | nM | 5.28 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 5904.35 | nM | 5.23 |
| CHEMBL3349342 | — | IC50 | = | 6029.86 | nM | 5.22 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 5965.42 | nM | 5.22 |
| CHEMBL803 | CYTARABINE | IC50 | = | 6708.03 | nM | 5.17 |
| CHEMBL217354 | — | IC50 | = | 7075.37 | nM | 5.15 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 7565.22 | nM | 5.12 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 9105.32 | nM | 5.04 |
| CHEMBL1190711 | — | IC50 | = | 9838.55 | nM | 5.01 |
| CHEMBL105442 | CI-1040 | IC50 | = | 10157.38 | nM | 4.99 |
| CHEMBL191384 | — | IC50 | = | 10840.82 | nM | 4.96 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 13217.74 | nM | 4.88 |
| CHEMBL221137 | EMBELIN | IC50 | = | 14178.86 | nM | 4.85 |
| CHEMBL399530 | — | IC50 | = | 17048.51 | nM | 4.77 |
| CHEMBL939 | GEFITINIB | IC50 | = | 17282.56 | nM | 4.76 |
| CHEMBL379975 | — | IC50 | = | 23104.03 | nM | 4.64 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 23468.12 | nM | 4.63 |
| CHEMBL2363137 | — | IC50 | = | 32967.82 | nM | 4.48 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 35881.83 | nM | 4.45 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 36365.7 | nM | 4.44 |
| CHEMBL202721 | — | IC50 | = | 43421.9 | nM | 4.36 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 43347.67 | nM | 4.36 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 46015.99 | nM | 4.34 |
| CHEMBL573107 | — | IC50 | = | 48678.53 | nM | 4.31 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 49446.24 | nM | 4.31 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 49686.09 | nM | 4.30 |
| CHEMBL572881 | MOTESANIB | IC50 | = | 53225.89 | nM | 4.27 |
| CHEMBL473417 | VISMODEGIB | IC50 | = | 57631.31 | nM | 4.24 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 60178.31 | nM | 4.22 |