Assay Detail
Functional
CHEMBL2363482
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SANGER: Inhibition of human NCI-H1651 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1651 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.45 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.43 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 8.30 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.27 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.93 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.83 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.68 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.64 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.61 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.38 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.22 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.08 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.46 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.42 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.30 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.30 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.25 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.16 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.10 |
| CHEMBL217354 | — | — | 1 | 6.00 |
| CHEMBL585951 | — | — | 1 | 5.97 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.96 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.59 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.49 |
| CHEMBL202721 | — | — | 1 | 5.43 |
| CHEMBL2363137 | — | — | 1 | 5.40 |
| CHEMBL1190711 | — | — | 1 | 5.38 |
| CHEMBL1173055 | RUCAPARIB | 4.0 | 1 | 5.36 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 5.35 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.30 |
| CHEMBL2137530 | SERDEMETAN | 2.0 | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 3.712 | nM | 8.43 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 4.99 | nM | 8.30 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 11.83 | nM | 7.93 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 14.95 | nM | 7.83 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 21.11 | nM | 7.68 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 24.31 | nM | 7.61 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 41.28 | nM | 7.38 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 60.64 | nM | 7.22 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 82.92 | nM | 7.08 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 344.18 | nM | 6.46 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 379.87 | nM | 6.42 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 505.3 | nM | 6.30 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 496.7 | nM | 6.30 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 563.43 | nM | 6.25 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 801.82 | nM | 6.10 |
| CHEMBL217354 | — | IC50 | = | 1001.07 | nM | 6.00 |
| CHEMBL585951 | — | IC50 | = | 1065.2 | nM | 5.97 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1093.52 | nM | 5.96 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 2582.1 | nM | 5.59 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3246.44 | nM | 5.49 |
| CHEMBL202721 | — | IC50 | = | 3744.15 | nM | 5.43 |
| CHEMBL2363137 | — | IC50 | = | 3944.58 | nM | 5.40 |
| CHEMBL1190711 | — | IC50 | = | 4147.94 | nM | 5.38 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 4353.99 | nM | 5.36 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 4460.27 | nM | 5.35 |
| CHEMBL803 | CYTARABINE | IC50 | = | 4984.74 | nM | 5.30 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 5199.43 | nM | 5.28 |
| CHEMBL221137 | EMBELIN | IC50 | = | 5977.65 | nM | 5.22 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 6653.28 | nM | 5.18 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 6707.71 | nM | 5.17 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 7062.3 | nM | 5.15 |
| CHEMBL591429 | PAC-1 | IC50 | = | 7700.41 | nM | 5.11 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 7802.43 | nM | 5.11 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 8225.61 | nM | 5.08 |
| CHEMBL2134202 | — | IC50 | = | 10027.56 | nM | 5.00 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 10232.65 | nM | 4.99 |
| CHEMBL191384 | — | IC50 | = | 11251.04 | nM | 4.95 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 11990.47 | nM | 4.92 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 12247.8 | nM | 4.91 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 12311.51 | nM | 4.91 |
| CHEMBL1186585 | — | IC50 | = | 13738.02 | nM | 4.86 |
| CHEMBL399530 | — | IC50 | = | 15062.44 | nM | 4.82 |
| CHEMBL1023 | BEXAROTENE | IC50 | = | 15261.42 | nM | 4.82 |
| CHEMBL258844 | — | IC50 | = | 16433.76 | nM | 4.78 |
| CHEMBL1090771 | AVAGACESTAT | IC50 | = | 20304.1 | nM | 4.69 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 20893.29 | nM | 4.68 |
| CHEMBL379975 | — | IC50 | = | 21163.39 | nM | 4.67 |