Assay Detail
Functional
CHEMBL2363508
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SANGER: Inhibition of human NCI-H2141 cell growth in a cell viability assay.
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H2141 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 5.48 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.39 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.86 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.41 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.09 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.07 |
| CHEMBL300389 | — | — | 1 | 6.99 |
| CHEMBL514499 | GW843682X | — | 1 | 6.80 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.72 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.62 |
| CHEMBL379300 | A-443654 | — | 1 | 6.27 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.24 |
| CHEMBL512504 | — | — | 1 | 6.20 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.19 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.16 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.07 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 5.98 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.92 |
| CHEMBL1256459 | TORIN1 | — | 1 | 5.92 |
| CHEMBL64925 | MG-132 | — | 2 | 5.78 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.77 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 5.53 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.50 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 5.50 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 5.36 |
| CHEMBL509032 | TAE-684 | — | 1 | 5.29 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.07 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 4.90 |
| CHEMBL1190711 | — | — | 1 | 4.87 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 4.79 |
| CHEMBL585951 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 4.046 | nM | 8.39 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 13.74 | nM | 7.86 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 38.99 | nM | 7.41 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 84.97 | nM | 7.07 |
| CHEMBL300389 | — | IC50 | = | 101.88 | nM | 6.99 |
| CHEMBL514499 | GW843682X | IC50 | = | 158.58 | nM | 6.80 |
| CHEMBL513909 | BI-2536 | IC50 | = | 190.11 | nM | 6.72 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 238.41 | nM | 6.62 |
| CHEMBL379300 | A-443654 | IC50 | = | 539.67 | nM | 6.27 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 573.69 | nM | 6.24 |
| CHEMBL512504 | — | IC50 | = | 632.66 | nM | 6.20 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 644.04 | nM | 6.19 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 698.19 | nM | 6.16 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 852.81 | nM | 6.07 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1051.24 | nM | 5.98 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1189.46 | nM | 5.92 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 1192.99 | nM | 5.92 |
| CHEMBL64925 | MG-132 | IC50 | = | 1673.17 | nM | 5.78 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1711.56 | nM | 5.77 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 2968.96 | nM | 5.53 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 3165.66 | nM | 5.50 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 3174.52 | nM | 5.50 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 4356.56 | nM | 5.36 |
| CHEMBL509032 | TAE-684 | IC50 | = | 5142.68 | nM | 5.29 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 8522.27 | nM | 5.07 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 12657.96 | nM | 4.90 |
| CHEMBL1190711 | — | IC50 | = | 13424.68 | nM | 4.87 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 16188.97 | nM | 4.79 |
| CHEMBL585951 | — | IC50 | = | 17764.53 | nM | 4.75 |
| CHEMBL64925 | MG-132 | IC50 | = | 19561.94 | nM | 4.71 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 21360.68 | nM | 4.67 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 24775.39 | nM | 4.61 |
| CHEMBL221137 | EMBELIN | IC50 | = | 26779.03 | nM | 4.57 |
| CHEMBL191384 | — | IC50 | = | 26947.62 | nM | 4.57 |
| CHEMBL401930 | — | IC50 | = | 27123.38 | nM | 4.57 |
| CHEMBL197603 | — | IC50 | = | 32749.8 | nM | 4.49 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 34653.34 | nM | 4.46 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 36115.53 | nM | 4.44 |
| CHEMBL535 | SUNITINIB | IC50 | = | 38084.3 | nM | 4.42 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 38032.95 | nM | 4.42 |
| CHEMBL373751 | GSK-319347A | IC50 | = | 39729.02 | nM | 4.40 |
| CHEMBL209148 | — | IC50 | = | 44978.56 | nM | 4.35 |
| CHEMBL1242367 | — | IC50 | = | 48847.25 | nM | 4.31 |
| CHEMBL2363137 | — | IC50 | = | 54746.8 | nM | 4.26 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 55443.42 | nM | 4.26 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 55562.53 | nM | 4.25 |
| CHEMBL591429 | PAC-1 | IC50 | = | 62694.64 | nM | 4.20 |
| CHEMBL228043 | — | IC50 | = | 274898.79 | nM | - |
| CHEMBL254129 | CYCLOPAMINE | IC50 | = | 2711133.25 | nM | - |