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Assay Detail

CHEMBL2363509

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Functional
SANGER: Inhibition of human NCI-H2170 cell growth in a cell viability assay.
ChEMBL ↗
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI-H2170
Confidence 1 — Organism
Curated By Autocuration

Target

NCI-H2170 (CHEMBL1075534) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 99 5.60 9.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL105 MITOMYCIN 4.0 1 9.82
CHEMBL94657 PATUPILONE 3.0 1 8.28
CHEMBL3545252 DOCETAXEL 4.0 1 8.27
CHEMBL553025 VINORELBINE 4.0 1 7.94
CHEMBL888 GEMCITABINE 4.0 1 7.92
CHEMBL65 CAMPTOTHECIN -1.0 1 7.86
CHEMBL96926 THAPSIGARGIN — 1 7.84
CHEMBL1972860 ELESCLOMOL 3.0 1 7.54
CHEMBL159 VINBLASTINE 4.0 1 7.48
CHEMBL1173655 AFATINIB 4.0 1 7.43
CHEMBL53463 DOXORUBICIN 4.0 1 6.96
CHEMBL1879463 DACTOLISIB 3.0 1 6.94
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.84
CHEMBL6067492 BLEOMYCIN 4.0 1 6.79
CHEMBL252164 LUMINESPIB 2.0 1 6.79
CHEMBL109480 TANESPIMYCIN 3.0 1 6.76
CHEMBL1201182 TEMSIROLIMUS 4.0 1 6.39
CHEMBL608533 MIDOSTAURIN 4.0 1 6.35
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.17
CHEMBL585951 — — 1 6.13
CHEMBL217354 — — 1 6.00
CHEMBL443684 NAVITOCLAX 3.0 1 5.97
CHEMBL2363137 — — 1 5.84
CHEMBL2041933 AZD-7762 1.0 1 5.82
CHEMBL575448 BMS-754807 2.0 1 5.78
CHEMBL9470 SHIKONIN — 1 5.76
CHEMBL44657 ETOPOSIDE 4.0 1 5.73
CHEMBL939 GEFITINIB 4.0 1 5.63
CHEMBL98 VORINOSTAT 4.0 1 5.60
CHEMBL1801204 AZD-8055 1.0 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL105 MITOMYCIN IC50 = 0.1513 nM 9.82
CHEMBL94657 PATUPILONE IC50 = 5.217 nM 8.28
CHEMBL3545252 DOCETAXEL IC50 = 5.348 nM 8.27
CHEMBL553025 VINORELBINE IC50 = 11.6 nM 7.94
CHEMBL888 GEMCITABINE IC50 = 11.97 nM 7.92
CHEMBL65 CAMPTOTHECIN IC50 = 13.71 nM 7.86
CHEMBL96926 THAPSIGARGIN IC50 = 14.4 nM 7.84
CHEMBL1972860 ELESCLOMOL IC50 = 28.85 nM 7.54
CHEMBL159 VINBLASTINE IC50 = 33.41 nM 7.48
CHEMBL1173655 AFATINIB IC50 = 37.28 nM 7.43
CHEMBL53463 DOXORUBICIN IC50 = 109.92 nM 6.96
CHEMBL1879463 DACTOLISIB IC50 = 114.51 nM 6.94
CHEMBL449158 BRYOSTATIN 1 IC50 = 143.54 nM 6.84
CHEMBL252164 LUMINESPIB IC50 = 163.04 nM 6.79
CHEMBL6067492 BLEOMYCIN IC50 = 162.42 nM 6.79
CHEMBL109480 TANESPIMYCIN IC50 = 175.36 nM 6.76
CHEMBL1201182 TEMSIROLIMUS IC50 = 404.7 nM 6.39
CHEMBL608533 MIDOSTAURIN IC50 = 443.53 nM 6.35
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 682.58 nM 6.17
CHEMBL585951 — IC50 = 744.53 nM 6.13
CHEMBL217354 — IC50 = 1001.69 nM 6.00
CHEMBL443684 NAVITOCLAX IC50 = 1062.3 nM 5.97
CHEMBL2363137 — IC50 = 1438.69 nM 5.84
CHEMBL2041933 AZD-7762 IC50 = 1523.13 nM 5.82
CHEMBL575448 BMS-754807 IC50 = 1644.99 nM 5.78
CHEMBL9470 SHIKONIN IC50 = 1717.23 nM 5.76
CHEMBL44657 ETOPOSIDE IC50 = 1852.85 nM 5.73
CHEMBL939 GEFITINIB IC50 = 2347.83 nM 5.63
CHEMBL98 VORINOSTAT IC50 = 2505.49 nM 5.60
CHEMBL1801204 AZD-8055 IC50 = 3004.51 nM 5.52
CHEMBL591429 PAC-1 IC50 = 3308.79 nM 5.48
CHEMBL803 CYTARABINE IC50 = 3356.41 nM 5.47
CHEMBL603469 LESTAURTINIB IC50 = 3511.37 nM 5.46
CHEMBL1171837 PONATINIB IC50 = 4667.71 nM 5.33
CHEMBL1190711 — IC50 = 5354.75 nM 5.27
CHEMBL399530 — IC50 = 7352.14 nM 5.13
CHEMBL34259 METHOTREXATE IC50 = 7859.67 nM 5.11
CHEMBL289228 TIPIFARNIB IC50 = 8386.71 nM 5.08
CHEMBL477772 PAZOPANIB IC50 = 9208.01 nM 5.04
CHEMBL259181 — IC50 = 11220.87 nM 4.95
CHEMBL202721 — IC50 = 11905.97 nM 4.92
CHEMBL221137 EMBELIN IC50 = 12109.42 nM 4.92
CHEMBL191384 — IC50 = 12208.37 nM 4.91
CHEMBL1023 BEXAROTENE IC50 = 13170.51 nM 4.88
CHEMBL507361 MIRDAMETINIB IC50 = 16586.96 nM 4.78
CHEMBL189963 PALBOCICLIB IC50 = 17244.82 nM 4.76
CHEMBL258844 — IC50 = 18102.77 nM 4.74
CHEMBL1091644 LINSITINIB IC50 = 18917.85 nM 4.72
CHEMBL577784 BX-795 IC50 = 23028.46 nM 4.64
CHEMBL11359 CISPLATIN IC50 = 23002.43 nM 4.64