Assay Detail
Functional
CHEMBL2363511
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SANGER: Inhibition of human NCI-H2196 cell growth in a cell viability assay.
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H2196 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 5.27 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.17 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.07 |
| CHEMBL300389 | — | — | 1 | 6.95 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.66 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.65 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.64 |
| CHEMBL512504 | — | — | 1 | 6.61 |
| CHEMBL514499 | GW843682X | — | 1 | 6.49 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.48 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.48 |
| CHEMBL4298697 | — | — | 1 | 6.19 |
| CHEMBL379300 | A-443654 | — | 1 | 6.19 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.18 |
| CHEMBL585951 | — | — | 1 | 6.11 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.05 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.01 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.00 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 5.64 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.47 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.39 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 5.38 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 5.29 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.15 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.12 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.05 |
| CHEMBL1190711 | — | — | 1 | 4.97 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 4.90 |
| CHEMBL191384 | — | — | 1 | 4.67 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 4.64 |
| CHEMBL258844 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 6.804 | nM | 8.17 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 84.45 | nM | 7.07 |
| CHEMBL300389 | — | IC50 | = | 111.67 | nM | 6.95 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 217.47 | nM | 6.66 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 222.35 | nM | 6.65 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 229.15 | nM | 6.64 |
| CHEMBL512504 | — | IC50 | = | 247.76 | nM | 6.61 |
| CHEMBL514499 | GW843682X | IC50 | = | 324.81 | nM | 6.49 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 330.36 | nM | 6.48 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 328.49 | nM | 6.48 |
| CHEMBL4298697 | — | IC50 | = | 645.37 | nM | 6.19 |
| CHEMBL379300 | A-443654 | IC50 | = | 648.41 | nM | 6.19 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 654.27 | nM | 6.18 |
| CHEMBL585951 | — | IC50 | = | 786.03 | nM | 6.11 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 886.0 | nM | 6.05 |
| CHEMBL513909 | BI-2536 | IC50 | = | 977.77 | nM | 6.01 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1012.22 | nM | 6.00 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 2310.34 | nM | 5.64 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 3350.08 | nM | 5.47 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 4056.25 | nM | 5.39 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 4171.69 | nM | 5.38 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 5172.8 | nM | 5.29 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 7071.34 | nM | 5.15 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 7494.86 | nM | 5.12 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 8986.06 | nM | 5.05 |
| CHEMBL1190711 | — | IC50 | = | 10771.98 | nM | 4.97 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 12592.04 | nM | 4.90 |
| CHEMBL191384 | — | IC50 | = | 21247.6 | nM | 4.67 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 22849.4 | nM | 4.64 |
| CHEMBL258844 | — | IC50 | = | 24800.28 | nM | 4.61 |
| CHEMBL509032 | TAE-684 | IC50 | = | 25911.66 | nM | 4.59 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 33255.69 | nM | 4.48 |
| CHEMBL515416 | — | IC50 | = | 34136.05 | nM | 4.47 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 40007.1 | nM | 4.40 |
| CHEMBL2363137 | — | IC50 | = | 53715.63 | nM | 4.27 |
| CHEMBL64925 | MG-132 | IC50 | = | 61231.02 | nM | 4.21 |
| CHEMBL64925 | MG-132 | IC50 | = | 62293.06 | nM | 4.21 |
| CHEMBL180127 | SALUBRINAL | IC50 | = | 63283.33 | nM | 4.20 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 69283.65 | nM | 4.16 |
| CHEMBL2144069 | — | IC50 | = | 71851.9 | nM | 4.14 |
| CHEMBL941 | IMATINIB | IC50 | = | 75637.86 | nM | 4.12 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 74904.5 | nM | 4.12 |
| CHEMBL483847 | — | IC50 | = | 86078.53 | nM | 4.07 |
| CHEMBL450786 | PHA-665752 | IC50 | = | 84994.37 | nM | 4.07 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 85182.24 | nM | 4.07 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 86487.16 | nM | 4.06 |
| CHEMBL135561 | — | IC50 | = | 92504.38 | nM | 4.03 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 99437.27 | nM | 4.00 |
| CHEMBL1023 | BEXAROTENE | IC50 | = | 1200935.36 | nM | - |
| CHEMBL213100 | — | IC50 | = | 351366.91 | nM | - |