Assay Detail
Functional
CHEMBL2363531
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SANGER: Inhibition of human NCI-H510A cell growth in a cell viability assay.
105
Total Activities
104
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H510A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 105 | 5.61 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.47 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.77 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.56 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.18 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.93 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.91 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.81 |
| CHEMBL514499 | GW843682X | — | 1 | 7.78 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.48 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.44 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 7.17 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.08 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 6.73 |
| CHEMBL379300 | A-443654 | — | 1 | 6.64 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.61 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.53 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.44 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.39 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.36 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.29 |
| CHEMBL512504 | — | — | 1 | 6.16 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.11 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.11 |
| CHEMBL300389 | — | — | 1 | 6.08 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.01 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.96 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 5.86 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 5.84 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.69 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.3363 | nM | 9.47 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 1.699 | nM | 8.77 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 2.753 | nM | 8.56 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6.652 | nM | 8.18 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 11.85 | nM | 7.93 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 12.39 | nM | 7.91 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 15.45 | nM | 7.81 |
| CHEMBL514499 | GW843682X | IC50 | = | 16.56 | nM | 7.78 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 33.27 | nM | 7.48 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 36.08 | nM | 7.44 |
| CHEMBL803 | CYTARABINE | IC50 | = | 68.26 | nM | 7.17 |
| CHEMBL513909 | BI-2536 | IC50 | = | 83.36 | nM | 7.08 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 185.37 | nM | 6.73 |
| CHEMBL379300 | A-443654 | IC50 | = | 229.2 | nM | 6.64 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 246.26 | nM | 6.61 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 293.04 | nM | 6.53 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 359.59 | nM | 6.44 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 402.82 | nM | 6.39 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 438.23 | nM | 6.36 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 512.76 | nM | 6.29 |
| CHEMBL512504 | — | IC50 | = | 691.72 | nM | 6.16 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 771.86 | nM | 6.11 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 772.36 | nM | 6.11 |
| CHEMBL300389 | — | IC50 | = | 838.13 | nM | 6.08 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 985.12 | nM | 6.01 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 1091.56 | nM | 5.96 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1381.42 | nM | 5.86 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1442.92 | nM | 5.84 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 2045.02 | nM | 5.69 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2644.26 | nM | 5.58 |
| CHEMBL1090090 | VX-702 | IC50 | = | 2925.26 | nM | 5.53 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 3103.77 | nM | 5.51 |
| CHEMBL509032 | TAE-684 | IC50 | = | 3189.43 | nM | 5.50 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 3827.24 | nM | 5.42 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 4791.54 | nM | 5.32 |
| CHEMBL197603 | — | IC50 | = | 4759.75 | nM | 5.32 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 5416.85 | nM | 5.27 |
| CHEMBL180127 | SALUBRINAL | IC50 | = | 7035.35 | nM | 5.15 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 8650.64 | nM | 5.06 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 11970.81 | nM | 4.92 |
| CHEMBL191384 | — | IC50 | = | 15021.87 | nM | 4.82 |
| CHEMBL941 | IMATINIB | IC50 | = | 17244.17 | nM | 4.76 |
| CHEMBL515416 | — | IC50 | = | 17609.47 | nM | 4.75 |
| CHEMBL1190711 | — | IC50 | = | 18081.71 | nM | 4.74 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 19397.28 | nM | 4.71 |
| CHEMBL2363137 | — | IC50 | = | 20240.55 | nM | 4.69 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 23793.94 | nM | 4.62 |
| CHEMBL535 | SUNITINIB | IC50 | = | 24127.78 | nM | 4.62 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 24551.67 | nM | 4.61 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 30032.86 | nM | 4.52 |