Assay Detail
Functional
CHEMBL2363533
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SANGER: Inhibition of human NCI-H522 cell growth in a cell viability assay.
72
Total Activities
71
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H522 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 72 | 5.60 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 9.27 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.20 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.36 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.27 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.71 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.29 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.27 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.77 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.74 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.61 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.37 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.37 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.34 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.25 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.20 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.06 |
| CHEMBL585951 | — | — | 1 | 6.05 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.93 |
| CHEMBL2363137 | — | — | 1 | 5.85 |
| CHEMBL217354 | — | — | 1 | 5.68 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.62 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.47 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.37 |
| CHEMBL191384 | — | — | 1 | 5.31 |
| CHEMBL2165191 | AZD-6482 | 2.0 | 2 | 5.28 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 5.20 |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | 5.16 |
| CHEMBL258844 | — | — | 1 | 4.96 |
| CHEMBL558642 | GSK-650394 | — | 1 | 4.88 |
| CHEMBL379975 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553025 | VINORELBINE | IC50 | = | 0.5354 | nM | 9.27 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.6353 | nM | 9.20 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 4.337 | nM | 8.36 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 5.43 | nM | 8.27 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 19.39 | nM | 7.71 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 51.93 | nM | 7.29 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 53.2 | nM | 7.27 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 169.45 | nM | 6.77 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 180.94 | nM | 6.74 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 248.31 | nM | 6.61 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 423.0 | nM | 6.37 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 425.69 | nM | 6.37 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 452.7 | nM | 6.34 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 559.79 | nM | 6.25 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 629.92 | nM | 6.20 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 877.83 | nM | 6.06 |
| CHEMBL585951 | — | IC50 | = | 886.79 | nM | 6.05 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 1164.68 | nM | 5.93 |
| CHEMBL2363137 | — | IC50 | = | 1404.24 | nM | 5.85 |
| CHEMBL217354 | — | IC50 | = | 2084.57 | nM | 5.68 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 2396.59 | nM | 5.62 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 3357.66 | nM | 5.47 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 4226.34 | nM | 5.37 |
| CHEMBL191384 | — | IC50 | = | 4934.52 | nM | 5.31 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 5196.01 | nM | 5.28 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 6333.06 | nM | 5.20 |
| CHEMBL591429 | PAC-1 | IC50 | = | 6939.79 | nM | 5.16 |
| CHEMBL258844 | — | IC50 | = | 11087.37 | nM | 4.96 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 13020.0 | nM | 4.88 |
| CHEMBL379975 | — | IC50 | = | 14097.37 | nM | 4.85 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 15330.56 | nM | 4.81 |
| CHEMBL577784 | BX-795 | IC50 | = | 17503.52 | nM | 4.76 |
| CHEMBL221137 | EMBELIN | IC50 | = | 17666.99 | nM | 4.75 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 20897.13 | nM | 4.68 |
| CHEMBL188678 | — | IC50 | = | 22843.12 | nM | 4.64 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 25878.88 | nM | 4.59 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 29833.86 | nM | 4.53 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 33654.0 | nM | 4.47 |
| CHEMBL255342 | — | IC50 | = | 34558.76 | nM | 4.46 |
| CHEMBL1190711 | — | IC50 | = | 39860.31 | nM | 4.40 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 44356.84 | nM | 4.35 |
| CHEMBL1186585 | — | IC50 | = | 48642.27 | nM | 4.31 |
| CHEMBL202721 | — | IC50 | = | 51708.59 | nM | 4.29 |
| CHEMBL399530 | — | IC50 | = | 55044.61 | nM | 4.26 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 70709.65 | nM | 4.15 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 72341.29 | nM | 4.14 |
| CHEMBL572881 | MOTESANIB | IC50 | = | 79327.43 | nM | 4.10 |
| CHEMBL135561 | — | IC50 | = | 81634.42 | nM | 4.09 |
| CHEMBL259181 | — | IC50 | = | 85279.07 | nM | 4.07 |
| CHEMBL472004 | — | IC50 | = | 1793038.6 | nM | - |