Assay Detail
Functional
CHEMBL2363549
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SANGER: Inhibition of human NCI-H82 cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H82 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.20 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.09 |
| CHEMBL514499 | GW843682X | — | 1 | 7.82 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.64 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.54 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.51 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.48 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.44 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.37 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.22 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.85 |
| CHEMBL379300 | A-443654 | — | 1 | 6.79 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.43 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.27 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.23 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.10 |
| CHEMBL300389 | — | — | 1 | 6.08 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.02 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 5.92 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 5.81 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.80 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.79 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 5.79 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 5.55 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.55 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 5.54 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.48 |
| CHEMBL1090090 | VX-702 | 2.0 | 1 | 5.41 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 5.40 |
| CHEMBL240954 | — | — | 1 | 5.30 |
| CHEMBL1289926 | AXITINIB | 4.0 | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 8.216 | nM | 8.09 |
| CHEMBL514499 | GW843682X | IC50 | = | 15.15 | nM | 7.82 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 23.02 | nM | 7.64 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 28.82 | nM | 7.54 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 31.09 | nM | 7.51 |
| CHEMBL513909 | BI-2536 | IC50 | = | 33.43 | nM | 7.48 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 36.63 | nM | 7.44 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 43.07 | nM | 7.37 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 60.02 | nM | 7.22 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 141.04 | nM | 6.85 |
| CHEMBL379300 | A-443654 | IC50 | = | 164.22 | nM | 6.79 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 372.97 | nM | 6.43 |
| CHEMBL939 | GEFITINIB | IC50 | = | 540.5 | nM | 6.27 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 588.29 | nM | 6.23 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 789.92 | nM | 6.10 |
| CHEMBL300389 | — | IC50 | = | 827.93 | nM | 6.08 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 958.22 | nM | 6.02 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1201.29 | nM | 5.92 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 1540.06 | nM | 5.81 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1570.26 | nM | 5.80 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 1642.17 | nM | 5.79 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1634.06 | nM | 5.79 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 2838.38 | nM | 5.55 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 2801.93 | nM | 5.55 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 2903.69 | nM | 5.54 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 3344.39 | nM | 5.48 |
| CHEMBL1090090 | VX-702 | IC50 | = | 3893.05 | nM | 5.41 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 3959.36 | nM | 5.40 |
| CHEMBL240954 | — | IC50 | = | 5062.16 | nM | 5.30 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 5927.71 | nM | 5.23 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 6204.89 | nM | 5.21 |
| CHEMBL188678 | — | IC50 | = | 7266.59 | nM | 5.14 |
| CHEMBL535 | SUNITINIB | IC50 | = | 7378.5 | nM | 5.13 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 7457.01 | nM | 5.13 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 9104.69 | nM | 5.04 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 9114.7 | nM | 5.04 |
| CHEMBL379975 | — | IC50 | = | 10537.78 | nM | 4.98 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 13290.87 | nM | 4.88 |
| CHEMBL189584 | PD-173074 | IC50 | = | 13419.49 | nM | 4.87 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 14626.44 | nM | 4.83 |
| CHEMBL1190711 | — | IC50 | = | 15452.89 | nM | 4.81 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 15532.01 | nM | 4.81 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 16121.49 | nM | 4.79 |
| CHEMBL38 | TRETINOIN | IC50 | = | 16922.06 | nM | 4.77 |
| CHEMBL222102 | KU-55933 | IC50 | = | 17457.25 | nM | 4.76 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 17872.8 | nM | 4.75 |
| CHEMBL2363137 | — | IC50 | = | 17993.2 | nM | 4.75 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 18018.32 | nM | 4.74 |
| CHEMBL573107 | — | IC50 | = | 19687.8 | nM | 4.71 |
| CHEMBL577784 | BX-795 | IC50 | = | 19427.06 | nM | 4.71 |