Assay Detail
Functional
CHEMBL2363573
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SANGER: Inhibition of human ONS-76 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ONS-76 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.82 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.48 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.62 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.49 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.48 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.43 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.39 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.06 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.00 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.99 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.84 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.72 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.69 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.69 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.54 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.53 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.48 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 7.21 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.20 |
| CHEMBL300389 | — | — | 1 | 7.12 |
| CHEMBL514499 | GW843682X | — | 1 | 7.11 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.03 |
| CHEMBL64925 | MG-132 | — | 2 | 6.89 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.88 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.87 |
| CHEMBL2144069 | — | — | 1 | 6.78 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.76 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 6.61 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.55 |
| CHEMBL217354 | — | — | 1 | 6.49 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 2.406 | nM | 8.62 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.217 | nM | 8.49 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 3.742 | nM | 8.43 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 4.099 | nM | 8.39 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 8.677 | nM | 8.06 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 9.981 | nM | 8.00 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 10.26 | nM | 7.99 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 14.51 | nM | 7.84 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 18.91 | nM | 7.72 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 20.36 | nM | 7.69 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 20.36 | nM | 7.69 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 29.05 | nM | 7.54 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 29.54 | nM | 7.53 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 33.03 | nM | 7.48 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 61.96 | nM | 7.21 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 63.77 | nM | 7.20 |
| CHEMBL300389 | — | IC50 | = | 76.09 | nM | 7.12 |
| CHEMBL514499 | GW843682X | IC50 | = | 77.85 | nM | 7.11 |
| CHEMBL513909 | BI-2536 | IC50 | = | 92.76 | nM | 7.03 |
| CHEMBL64925 | MG-132 | IC50 | = | 129.35 | nM | 6.89 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 131.3 | nM | 6.88 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 136.01 | nM | 6.87 |
| CHEMBL2144069 | — | IC50 | = | 166.62 | nM | 6.78 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 171.85 | nM | 6.76 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 244.53 | nM | 6.61 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 278.41 | nM | 6.55 |
| CHEMBL217354 | — | IC50 | = | 325.26 | nM | 6.49 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 329.56 | nM | 6.48 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 358.07 | nM | 6.45 |
| CHEMBL803 | CYTARABINE | IC50 | = | 390.03 | nM | 6.41 |
| CHEMBL585951 | — | IC50 | = | 396.14 | nM | 6.40 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 429.51 | nM | 6.37 |
| CHEMBL379300 | A-443654 | IC50 | = | 443.96 | nM | 6.35 |
| CHEMBL3349342 | — | IC50 | = | 500.44 | nM | 6.30 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 582.42 | nM | 6.24 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 664.58 | nM | 6.18 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 677.82 | nM | 6.17 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 754.29 | nM | 6.12 |
| CHEMBL135561 | — | IC50 | = | 838.5 | nM | 6.08 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 853.91 | nM | 6.07 |
| CHEMBL64925 | MG-132 | IC50 | = | 899.04 | nM | 6.05 |
| CHEMBL105442 | CI-1040 | IC50 | = | 1220.49 | nM | 5.91 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 1378.92 | nM | 5.86 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1467.12 | nM | 5.83 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1523.11 | nM | 5.82 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 1535.69 | nM | 5.81 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1675.51 | nM | 5.78 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1828.97 | nM | 5.74 |