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Assay Detail

CHEMBL2363574

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Functional
SANGER: Inhibition of human OPM-2 cell growth in a cell viability assay.
ChEMBL ↗
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type OPM-2
Confidence 1 — Organism
Curated By Autocuration

Target

OPM-2 (CHEMBL2366353) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 78 5.74 9.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL96926 THAPSIGARGIN — 1 9.66
CHEMBL325041 BORTEZOMIB 3.0 1 8.88
CHEMBL413 SIROLIMUS 4.0 1 8.38
CHEMBL553025 VINORELBINE 4.0 1 8.20
CHEMBL1256459 TORIN1 — 1 7.89
CHEMBL428647 PACLITAXEL 4.0 1 7.43
CHEMBL514499 GW843682X — 1 7.35
CHEMBL94657 PATUPILONE 3.0 1 7.19
CHEMBL64925 MG-132 — 2 6.98
CHEMBL300389 — — 1 6.82
CHEMBL512504 — — 1 6.66
CHEMBL509032 TAE-684 — 1 6.64
CHEMBL513909 BI-2536 2.0 1 6.62
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.54
CHEMBL252164 LUMINESPIB 2.0 1 6.51
CHEMBL379300 A-443654 — 1 6.50
CHEMBL9470 SHIKONIN — 1 6.46
CHEMBL1171837 PONATINIB 4.0 1 6.44
CHEMBL27759 ENTINOSTAT 3.0 1 6.38
CHEMBL53463 DOXORUBICIN 4.0 1 6.30
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.29
CHEMBL585951 — — 1 6.29
CHEMBL401930 — — 1 6.28
CHEMBL575448 BMS-754807 2.0 1 6.21
CHEMBL608533 MIDOSTAURIN 4.0 1 5.78
CHEMBL1091644 LINSITINIB 3.0 1 5.68
CHEMBL1084546 PF-00562271 1.0 1 5.54
CHEMBL2144069 — — 1 5.52
CHEMBL535 SUNITINIB 4.0 1 5.51
CHEMBL1673039 — — 1 5.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL96926 THAPSIGARGIN IC50 = 0.2164 nM 9.66
CHEMBL325041 BORTEZOMIB IC50 = 1.326 nM 8.88
CHEMBL413 SIROLIMUS IC50 = 4.15 nM 8.38
CHEMBL553025 VINORELBINE IC50 = 6.273 nM 8.20
CHEMBL1256459 TORIN1 IC50 = 12.9 nM 7.89
CHEMBL428647 PACLITAXEL IC50 = 36.73 nM 7.43
CHEMBL514499 GW843682X IC50 = 44.24 nM 7.35
CHEMBL94657 PATUPILONE IC50 = 64.46 nM 7.19
CHEMBL64925 MG-132 IC50 = 104.74 nM 6.98
CHEMBL300389 — IC50 = 153.04 nM 6.82
CHEMBL512504 — IC50 = 217.91 nM 6.66
CHEMBL509032 TAE-684 IC50 = 226.69 nM 6.64
CHEMBL513909 BI-2536 IC50 = 238.82 nM 6.62
CHEMBL449158 BRYOSTATIN 1 IC50 = 285.99 nM 6.54
CHEMBL252164 LUMINESPIB IC50 = 310.64 nM 6.51
CHEMBL379300 A-443654 IC50 = 314.39 nM 6.50
CHEMBL9470 SHIKONIN IC50 = 343.26 nM 6.46
CHEMBL1171837 PONATINIB IC50 = 364.73 nM 6.44
CHEMBL27759 ENTINOSTAT IC50 = 415.13 nM 6.38
CHEMBL53463 DOXORUBICIN IC50 = 501.81 nM 6.30
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 509.37 nM 6.29
CHEMBL585951 — IC50 = 513.88 nM 6.29
CHEMBL401930 — IC50 = 525.25 nM 6.28
CHEMBL575448 BMS-754807 IC50 = 611.61 nM 6.21
CHEMBL64925 MG-132 IC50 = 758.37 nM 6.12
CHEMBL608533 MIDOSTAURIN IC50 = 1658.01 nM 5.78
CHEMBL1091644 LINSITINIB IC50 = 2102.0 nM 5.68
CHEMBL1084546 PF-00562271 IC50 = 2899.78 nM 5.54
CHEMBL2144069 — IC50 = 3034.2 nM 5.52
CHEMBL535 SUNITINIB IC50 = 3059.54 nM 5.51
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 3292.97 nM 5.48
CHEMBL1673039 — IC50 = 3300.13 nM 5.48
CHEMBL5416410 DASATINIB IC50 = 4276.85 nM 5.37
CHEMBL1190711 — IC50 = 6159.66 nM 5.21
CHEMBL105 MITOMYCIN IC50 = 6348.57 nM 5.20
CHEMBL209148 — IC50 = 8909.77 nM 5.05
CHEMBL572878 TOZASERTIB IC50 = 12159.56 nM 4.92
CHEMBL601719 CRIZOTINIB IC50 = 14408.54 nM 4.84
CHEMBL1242367 — IC50 = 14565.1 nM 4.84
CHEMBL591429 PAC-1 IC50 = 15137.12 nM 4.82
CHEMBL515416 — IC50 = 16487.29 nM 4.78
CHEMBL888 GEMCITABINE IC50 = 17633.65 nM 4.75
CHEMBL36 PYRIMETHAMINE IC50 = 22078.96 nM 4.66
CHEMBL44657 ETOPOSIDE IC50 = 24611.78 nM 4.61
CHEMBL213100 — IC50 = 25105.98 nM 4.60
CHEMBL92309 — IC50 = 28822.69 nM 4.54
CHEMBL2363137 — IC50 = 32567.5 nM 4.49
CHEMBL14762 SELICICLIB IC50 = 37294.95 nM 4.43
CHEMBL472940 — IC50 = 38025.16 nM 4.42
CHEMBL1336 SORAFENIB IC50 = 39843.17 nM 4.40