Assay Detail
Functional
CHEMBL2363577
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human OVCAR-4 cell growth in a cell viability assay.
138
Total Activities
136
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OVCAR-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 138 | 5.46 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.54 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.79 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.76 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.53 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.23 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.23 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.04 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.55 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.51 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.41 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.39 |
| CHEMBL514499 | GW843682X | — | 1 | 7.15 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.13 |
| CHEMBL64925 | MG-132 | — | 2 | 6.96 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.80 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.72 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.69 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.62 |
| CHEMBL379300 | A-443654 | — | 1 | 6.61 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.50 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.49 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 6.43 |
| CHEMBL509032 | TAE-684 | — | 1 | 6.39 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.38 |
| CHEMBL585951 | — | — | 1 | 6.33 |
| CHEMBL217354 | — | — | 1 | 6.21 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.20 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.17 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.16 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.2893 | nM | 9.54 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.612 | nM | 8.79 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 1.745 | nM | 8.76 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 2.928 | nM | 8.53 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 5.856 | nM | 8.23 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 5.87 | nM | 8.23 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 9.041 | nM | 8.04 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 27.94 | nM | 7.55 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 30.94 | nM | 7.51 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 38.58 | nM | 7.41 |
| CHEMBL513909 | BI-2536 | IC50 | = | 40.59 | nM | 7.39 |
| CHEMBL514499 | GW843682X | IC50 | = | 71.45 | nM | 7.15 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 73.36 | nM | 7.13 |
| CHEMBL64925 | MG-132 | IC50 | = | 109.38 | nM | 6.96 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 156.78 | nM | 6.80 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 188.55 | nM | 6.72 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 206.28 | nM | 6.69 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 237.24 | nM | 6.62 |
| CHEMBL379300 | A-443654 | IC50 | = | 243.27 | nM | 6.61 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 320.21 | nM | 6.50 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 322.8 | nM | 6.49 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 374.33 | nM | 6.43 |
| CHEMBL509032 | TAE-684 | IC50 | = | 405.69 | nM | 6.39 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 415.86 | nM | 6.38 |
| CHEMBL585951 | — | IC50 | = | 467.27 | nM | 6.33 |
| CHEMBL217354 | — | IC50 | = | 609.53 | nM | 6.21 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 625.23 | nM | 6.20 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 669.55 | nM | 6.17 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 696.91 | nM | 6.16 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 819.11 | nM | 6.09 |
| CHEMBL197603 | — | IC50 | = | 1036.15 | nM | 5.99 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1131.65 | nM | 5.95 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 1450.8 | nM | 5.84 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 1551.93 | nM | 5.81 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 1696.07 | nM | 5.77 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1847.7 | nM | 5.73 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 2004.35 | nM | 5.70 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 2211.9 | nM | 5.66 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 2213.93 | nM | 5.66 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 2461.3 | nM | 5.61 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 2527.92 | nM | 5.60 |
| CHEMBL591429 | PAC-1 | IC50 | = | 3535.84 | nM | 5.45 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 3734.33 | nM | 5.43 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 3801.36 | nM | 5.42 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3928.89 | nM | 5.41 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 4153.27 | nM | 5.38 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 4414.18 | nM | 5.36 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 4410.35 | nM | 5.36 |
| CHEMBL515416 | — | IC50 | = | 4325.19 | nM | 5.36 |
| CHEMBL2363137 | — | IC50 | = | 4605.89 | nM | 5.34 |