Assay Detail
Functional
CHEMBL2363581
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SANGER: Inhibition of human P30-OHK cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | P30-OHK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.79 | 8.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.84 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.68 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.55 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.35 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 8.31 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.00 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.96 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.36 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.26 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 7.25 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.24 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.21 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.08 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.89 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.88 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.80 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.66 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.62 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.58 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.57 |
| CHEMBL585951 | — | — | 1 | 6.53 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.49 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.41 |
| CHEMBL1190711 | — | — | 1 | 6.37 |
| CHEMBL577784 | BX-795 | — | 1 | 6.30 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.21 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.19 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.14 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.08 |
| CHEMBL512504 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 1.459 | nM | 8.84 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 2.08 | nM | 8.68 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 2.792 | nM | 8.55 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 4.49 | nM | 8.35 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 4.842 | nM | 8.31 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 11.07 | nM | 7.96 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 43.55 | nM | 7.36 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 54.61 | nM | 7.26 |
| CHEMBL803 | CYTARABINE | IC50 | = | 56.5 | nM | 7.25 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 57.57 | nM | 7.24 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 61.67 | nM | 7.21 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 83.5 | nM | 7.08 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 127.5 | nM | 6.89 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 131.6 | nM | 6.88 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 156.72 | nM | 6.80 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 220.48 | nM | 6.66 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 240.5 | nM | 6.62 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 263.88 | nM | 6.58 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 269.05 | nM | 6.57 |
| CHEMBL585951 | — | IC50 | = | 298.82 | nM | 6.53 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 327.05 | nM | 6.49 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 392.04 | nM | 6.41 |
| CHEMBL1190711 | — | IC50 | = | 426.87 | nM | 6.37 |
| CHEMBL577784 | BX-795 | IC50 | = | 496.5 | nM | 6.30 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 612.46 | nM | 6.21 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 641.88 | nM | 6.19 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 730.71 | nM | 6.14 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 835.7 | nM | 6.08 |
| CHEMBL512504 | — | IC50 | = | 992.92 | nM | 6.00 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 1046.88 | nM | 5.98 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 1060.27 | nM | 5.97 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 1071.38 | nM | 5.97 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1211.24 | nM | 5.92 |
| CHEMBL379975 | — | IC50 | = | 1910.83 | nM | 5.72 |
| CHEMBL300389 | — | IC50 | = | 2352.64 | nM | 5.63 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 2707.2 | nM | 5.57 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 3201.17 | nM | 5.50 |
| CHEMBL259181 | — | IC50 | = | 3560.14 | nM | 5.45 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 3809.76 | nM | 5.42 |
| CHEMBL258844 | — | IC50 | = | 4536.0 | nM | 5.34 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 4665.81 | nM | 5.33 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 4680.08 | nM | 5.33 |
| CHEMBL939 | GEFITINIB | IC50 | = | 4819.29 | nM | 5.32 |
| CHEMBL191384 | — | IC50 | = | 4750.6 | nM | 5.32 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 5350.52 | nM | 5.27 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 5469.4 | nM | 5.26 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 6209.93 | nM | 5.21 |
| CHEMBL221137 | EMBELIN | IC50 | = | 6130.2 | nM | 5.21 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 6627.7 | nM | 5.18 |