Assay Detail
Functional
CHEMBL2363583
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SANGER: Inhibition of human PA-1 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PA-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.96 | 9.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.76 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.16 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.16 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 9.01 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 8.83 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.51 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.09 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.05 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.05 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.93 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.63 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.56 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.35 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.06 |
| CHEMBL585951 | — | — | 1 | 6.99 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.88 |
| CHEMBL217354 | — | — | 1 | 6.87 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.85 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.73 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.73 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.70 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.54 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.47 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 6.29 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.27 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.12 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 6.10 |
| CHEMBL577784 | BX-795 | — | 1 | 6.09 |
| CHEMBL191334 | NUTLIN-3 | — | 1 | 6.06 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.1737 | nM | 9.76 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.6981 | nM | 9.16 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.6873 | nM | 9.16 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.981 | nM | 9.01 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 1.47 | nM | 8.83 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 3.123 | nM | 8.51 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 8.092 | nM | 8.09 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 8.993 | nM | 8.05 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 8.844 | nM | 8.05 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 11.82 | nM | 7.93 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 23.51 | nM | 7.63 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 27.55 | nM | 7.56 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 44.48 | nM | 7.35 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 87.69 | nM | 7.06 |
| CHEMBL585951 | — | IC50 | = | 102.36 | nM | 6.99 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 132.19 | nM | 6.88 |
| CHEMBL217354 | — | IC50 | = | 133.66 | nM | 6.87 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 140.01 | nM | 6.85 |
| CHEMBL803 | CYTARABINE | IC50 | = | 186.65 | nM | 6.73 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 184.99 | nM | 6.73 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 201.28 | nM | 6.70 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 286.26 | nM | 6.54 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 336.19 | nM | 6.47 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 509.86 | nM | 6.29 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 532.41 | nM | 6.27 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 749.68 | nM | 6.12 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 789.94 | nM | 6.10 |
| CHEMBL577784 | BX-795 | IC50 | = | 804.22 | nM | 6.09 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 870.96 | nM | 6.06 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 956.42 | nM | 6.02 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 954.24 | nM | 6.02 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 965.43 | nM | 6.01 |
| CHEMBL1190711 | — | IC50 | = | 1009.16 | nM | 6.00 |
| CHEMBL393929 | — | IC50 | = | 1226.54 | nM | 5.91 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 1352.65 | nM | 5.87 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1336.54 | nM | 5.87 |
| CHEMBL191384 | — | IC50 | = | 1530.64 | nM | 5.82 |
| CHEMBL188678 | — | IC50 | = | 1582.94 | nM | 5.80 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 1827.25 | nM | 5.74 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 2015.27 | nM | 5.70 |
| CHEMBL221137 | EMBELIN | IC50 | = | 2321.84 | nM | 5.63 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 2433.04 | nM | 5.61 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 2726.73 | nM | 5.56 |
| CHEMBL202721 | — | IC50 | = | 2865.23 | nM | 5.54 |
| CHEMBL2363137 | — | IC50 | = | 2902.76 | nM | 5.54 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 3008.32 | nM | 5.52 |
| CHEMBL379975 | — | IC50 | = | 3104.23 | nM | 5.51 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 3330.83 | nM | 5.48 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 3300.59 | nM | 5.48 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 3797.82 | nM | 5.42 |