Assay Detail
Functional
CHEMBL2363587
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SANGER: Inhibition of human PC-14 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-14 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.74 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.68 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.49 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.45 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.38 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.10 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.87 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.71 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.61 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.36 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.33 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.28 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 7.25 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.88 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.74 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.69 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.63 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.50 |
| CHEMBL217354 | — | — | 1 | 6.48 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.48 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.38 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.35 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.31 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.27 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.24 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.23 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.21 |
| CHEMBL585951 | — | — | 1 | 6.06 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 5.89 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.82 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 2.092 | nM | 8.68 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 3.26 | nM | 8.49 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 3.534 | nM | 8.45 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 4.214 | nM | 8.38 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 8.013 | nM | 8.10 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 13.58 | nM | 7.87 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 19.34 | nM | 7.71 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 24.73 | nM | 7.61 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 43.33 | nM | 7.36 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 46.57 | nM | 7.33 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 52.52 | nM | 7.28 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 56.68 | nM | 7.25 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 132.11 | nM | 6.88 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 182.69 | nM | 6.74 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 203.31 | nM | 6.69 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 236.12 | nM | 6.63 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 318.99 | nM | 6.50 |
| CHEMBL217354 | — | IC50 | = | 330.63 | nM | 6.48 |
| CHEMBL939 | GEFITINIB | IC50 | = | 333.41 | nM | 6.48 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 416.61 | nM | 6.38 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 449.49 | nM | 6.35 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 491.27 | nM | 6.31 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 538.55 | nM | 6.27 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 572.86 | nM | 6.24 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 589.7 | nM | 6.23 |
| CHEMBL803 | CYTARABINE | IC50 | = | 609.5 | nM | 6.21 |
| CHEMBL585951 | — | IC50 | = | 876.6 | nM | 6.06 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1292.05 | nM | 5.89 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1507.16 | nM | 5.82 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2805.1 | nM | 5.55 |
| CHEMBL191384 | — | IC50 | = | 3618.05 | nM | 5.44 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 3664.37 | nM | 5.44 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 3732.22 | nM | 5.43 |
| CHEMBL3349342 | — | IC50 | = | 4165.69 | nM | 5.38 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 5722.78 | nM | 5.24 |
| CHEMBL399530 | — | IC50 | = | 6742.23 | nM | 5.17 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 9722.34 | nM | 5.01 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 12323.98 | nM | 4.91 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 14254.58 | nM | 4.85 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 14965.42 | nM | 4.83 |
| CHEMBL221137 | EMBELIN | IC50 | = | 15584.86 | nM | 4.81 |
| CHEMBL105442 | CI-1040 | IC50 | = | 15486.61 | nM | 4.81 |
| CHEMBL135561 | — | IC50 | = | 15571.03 | nM | 4.81 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 16490.23 | nM | 4.78 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 16495.95 | nM | 4.78 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 18390.37 | nM | 4.74 |
| CHEMBL2363137 | — | IC50 | = | 20028.21 | nM | 4.70 |
| CHEMBL573107 | — | IC50 | = | 20183.41 | nM | 4.70 |
| CHEMBL228043 | — | IC50 | = | 20867.94 | nM | 4.68 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 23662.3 | nM | 4.63 |