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Assay Detail

CHEMBL2363589

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Functional
SANGER: Inhibition of human PF-382 cell growth in a cell viability assay.
ChEMBL ↗
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PF-382
Confidence 1 — Organism
Curated By Autocuration

Target

PF-382 (CHEMBL2366235) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 78 5.82 8.83

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL325041 BORTEZOMIB 3.0 1 8.83
CHEMBL94657 PATUPILONE 3.0 1 8.06
CHEMBL553025 VINORELBINE 4.0 1 7.93
CHEMBL428647 PACLITAXEL 4.0 1 7.62
CHEMBL96926 THAPSIGARGIN — 1 7.59
CHEMBL514499 GW843682X — 1 7.48
CHEMBL513909 BI-2536 2.0 1 7.38
CHEMBL888 GEMCITABINE 4.0 1 7.35
CHEMBL252164 LUMINESPIB 2.0 1 7.32
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 7.31
CHEMBL53463 DOXORUBICIN 4.0 1 7.17
CHEMBL1256459 TORIN1 — 1 7.12
CHEMBL512504 — — 1 7.07
CHEMBL413 SIROLIMUS 4.0 1 7.01
CHEMBL300389 — — 1 6.98
CHEMBL64925 MG-132 — 2 6.78
CHEMBL5416410 DASATINIB 4.0 1 6.75
CHEMBL1171837 PONATINIB 4.0 1 6.68
CHEMBL105 MITOMYCIN 4.0 1 6.60
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.56
CHEMBL608533 MIDOSTAURIN 4.0 1 6.41
CHEMBL6067492 BLEOMYCIN 4.0 1 6.37
CHEMBL585951 — — 1 6.32
CHEMBL379300 A-443654 — 1 6.20
CHEMBL213100 — — 1 6.15
CHEMBL44657 ETOPOSIDE 4.0 1 6.14
CHEMBL9470 SHIKONIN — 1 6.10
CHEMBL591429 PAC-1 1.0 1 5.97
CHEMBL27759 ENTINOSTAT 3.0 1 5.95
CHEMBL515416 — — 1 5.91

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL325041 BORTEZOMIB IC50 = 1.47 nM 8.83
CHEMBL94657 PATUPILONE IC50 = 8.684 nM 8.06
CHEMBL553025 VINORELBINE IC50 = 11.72 nM 7.93
CHEMBL428647 PACLITAXEL IC50 = 23.78 nM 7.62
CHEMBL96926 THAPSIGARGIN IC50 = 25.87 nM 7.59
CHEMBL514499 GW843682X IC50 = 33.43 nM 7.48
CHEMBL513909 BI-2536 IC50 = 41.98 nM 7.38
CHEMBL888 GEMCITABINE IC50 = 44.22 nM 7.35
CHEMBL252164 LUMINESPIB IC50 = 48.26 nM 7.32
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 49.39 nM 7.31
CHEMBL53463 DOXORUBICIN IC50 = 67.17 nM 7.17
CHEMBL1256459 TORIN1 IC50 = 75.69 nM 7.12
CHEMBL512504 — IC50 = 85.9 nM 7.07
CHEMBL413 SIROLIMUS IC50 = 96.79 nM 7.01
CHEMBL300389 — IC50 = 104.1 nM 6.98
CHEMBL64925 MG-132 IC50 = 167.06 nM 6.78
CHEMBL5416410 DASATINIB IC50 = 176.78 nM 6.75
CHEMBL1171837 PONATINIB IC50 = 208.73 nM 6.68
CHEMBL105 MITOMYCIN IC50 = 250.63 nM 6.60
CHEMBL449158 BRYOSTATIN 1 IC50 = 273.78 nM 6.56
CHEMBL608533 MIDOSTAURIN IC50 = 387.56 nM 6.41
CHEMBL6067492 BLEOMYCIN IC50 = 426.16 nM 6.37
CHEMBL585951 — IC50 = 475.58 nM 6.32
CHEMBL64925 MG-132 IC50 = 583.79 nM 6.23
CHEMBL379300 A-443654 IC50 = 637.67 nM 6.20
CHEMBL213100 — IC50 = 707.63 nM 6.15
CHEMBL44657 ETOPOSIDE IC50 = 723.88 nM 6.14
CHEMBL9470 SHIKONIN IC50 = 789.51 nM 6.10
CHEMBL591429 PAC-1 IC50 = 1058.87 nM 5.97
CHEMBL27759 ENTINOSTAT IC50 = 1115.13 nM 5.95
CHEMBL515416 — IC50 = 1218.1 nM 5.91
CHEMBL509032 TAE-684 IC50 = 1569.6 nM 5.80
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 1666.67 nM 5.78
CHEMBL289228 TIPIFARNIB IC50 = 1714.4 nM 5.77
CHEMBL1190711 — IC50 = 2405.89 nM 5.62
CHEMBL2144069 — IC50 = 3052.37 nM 5.51
CHEMBL572878 TOZASERTIB IC50 = 3357.78 nM 5.47
CHEMBL535 SUNITINIB IC50 = 3445.7 nM 5.46
CHEMBL217092 SARACATINIB IC50 = 3836.98 nM 5.42
CHEMBL1673039 — IC50 = 4944.71 nM 5.31
CHEMBL472940 — IC50 = 5352.26 nM 5.27
CHEMBL221137 EMBELIN IC50 = 6166.73 nM 5.21
CHEMBL220241 GSK-269962A IC50 = 7049.54 nM 5.15
CHEMBL2363137 — IC50 = 7728.59 nM 5.11
CHEMBL2165191 AZD-6482 IC50 = 9898.65 nM 5.00
CHEMBL258844 — IC50 = 11682.77 nM 4.93
CHEMBL1242367 — IC50 = 14311.42 nM 4.84
CHEMBL36 PYRIMETHAMINE IC50 = 14586.77 nM 4.84
CHEMBL401930 — IC50 = 18889.29 nM 4.72
CHEMBL1336 SORAFENIB IC50 = 21440.31 nM 4.67