Assay Detail
Functional
CHEMBL2363599
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human RH-1 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RH-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.72 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.41 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.00 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.47 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.41 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.17 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.96 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 7.75 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.42 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.36 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.30 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.26 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.24 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.21 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.00 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.83 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.82 |
| CHEMBL217354 | — | — | 1 | 6.80 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.78 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.65 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.64 |
| CHEMBL514499 | GW843682X | — | 1 | 6.62 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.55 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.50 |
| CHEMBL300389 | — | — | 1 | 6.48 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.48 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.44 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.31 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.15 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.14 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.3856 | nM | 9.41 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.9968 | nM | 9.00 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 3.86 | nM | 8.41 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 6.733 | nM | 8.17 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 11.02 | nM | 7.96 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 17.78 | nM | 7.75 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 38.19 | nM | 7.42 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 43.42 | nM | 7.36 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 49.57 | nM | 7.30 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 54.7 | nM | 7.26 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 58.17 | nM | 7.24 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 62.3 | nM | 7.21 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 99.85 | nM | 7.00 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 149.06 | nM | 6.83 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 152.21 | nM | 6.82 |
| CHEMBL217354 | — | IC50 | = | 157.72 | nM | 6.80 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 166.29 | nM | 6.78 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 222.42 | nM | 6.65 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 226.66 | nM | 6.64 |
| CHEMBL514499 | GW843682X | IC50 | = | 242.4 | nM | 6.62 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 279.89 | nM | 6.55 |
| CHEMBL513909 | BI-2536 | IC50 | = | 318.71 | nM | 6.50 |
| CHEMBL300389 | — | IC50 | = | 333.42 | nM | 6.48 |
| CHEMBL803 | CYTARABINE | IC50 | = | 328.16 | nM | 6.48 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 361.82 | nM | 6.44 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 487.24 | nM | 6.31 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 715.17 | nM | 6.15 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 719.88 | nM | 6.14 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 748.59 | nM | 6.13 |
| CHEMBL585951 | — | IC50 | = | 918.86 | nM | 6.04 |
| CHEMBL939 | GEFITINIB | IC50 | = | 1411.36 | nM | 5.85 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1567.62 | nM | 5.80 |
| CHEMBL577784 | BX-795 | IC50 | = | 1702.74 | nM | 5.77 |
| CHEMBL512504 | — | IC50 | = | 2139.33 | nM | 5.67 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 2500.43 | nM | 5.60 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 2749.12 | nM | 5.56 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3102.78 | nM | 5.51 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 3172.91 | nM | 5.50 |
| CHEMBL64925 | MG-132 | IC50 | = | 3387.48 | nM | 5.47 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 3684.63 | nM | 5.43 |
| CHEMBL1190711 | — | IC50 | = | 4671.59 | nM | 5.33 |
| CHEMBL259181 | — | IC50 | = | 5291.07 | nM | 5.28 |
| CHEMBL379975 | — | IC50 | = | 5734.31 | nM | 5.24 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 6637.43 | nM | 5.18 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 7852.44 | nM | 5.11 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 7734.3 | nM | 5.11 |
| CHEMBL1186585 | — | IC50 | = | 8306.74 | nM | 5.08 |
| CHEMBL591429 | PAC-1 | IC50 | = | 8617.63 | nM | 5.07 |
| CHEMBL191384 | — | IC50 | = | 9843.91 | nM | 5.01 |