Assay Detail
Functional
CHEMBL2363607
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SANGER: Inhibition of human RPMI-6666 cell growth in a cell viability assay.
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-6666 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 5.80 | 10.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 10.19 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.82 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.16 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 8.13 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.07 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.67 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.61 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.37 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.34 |
| CHEMBL300389 | — | — | 1 | 7.30 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.18 |
| CHEMBL512504 | — | — | 1 | 7.17 |
| CHEMBL514499 | GW843682X | — | 1 | 7.08 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.05 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.89 |
| CHEMBL379300 | A-443654 | — | 1 | 6.82 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.66 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.54 |
| CHEMBL585951 | — | — | 1 | 6.53 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.39 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.35 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.28 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.23 |
| CHEMBL2165191 | AZD-6482 | 2.0 | 1 | 6.19 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.00 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.99 |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | 5.98 |
| CHEMBL1190711 | — | — | 1 | 5.84 |
| CHEMBL197603 | — | — | 1 | 5.80 |
| CHEMBL64925 | MG-132 | — | 2 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.06524 | nM | 10.19 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.498 | nM | 8.82 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 6.862 | nM | 8.16 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 7.407 | nM | 8.13 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 8.517 | nM | 8.07 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 21.49 | nM | 7.67 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 24.42 | nM | 7.61 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 42.65 | nM | 7.37 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 45.89 | nM | 7.34 |
| CHEMBL300389 | — | IC50 | = | 50.41 | nM | 7.30 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 65.99 | nM | 7.18 |
| CHEMBL512504 | — | IC50 | = | 67.98 | nM | 7.17 |
| CHEMBL514499 | GW843682X | IC50 | = | 82.64 | nM | 7.08 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 89.67 | nM | 7.05 |
| CHEMBL513909 | BI-2536 | IC50 | = | 127.43 | nM | 6.89 |
| CHEMBL379300 | A-443654 | IC50 | = | 151.72 | nM | 6.82 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 219.61 | nM | 6.66 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 288.4 | nM | 6.54 |
| CHEMBL585951 | — | IC50 | = | 296.23 | nM | 6.53 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 411.2 | nM | 6.39 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 445.05 | nM | 6.35 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 521.35 | nM | 6.28 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 587.13 | nM | 6.23 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 643.79 | nM | 6.19 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1010.54 | nM | 6.00 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1032.21 | nM | 5.99 |
| CHEMBL591429 | PAC-1 | IC50 | = | 1036.48 | nM | 5.98 |
| CHEMBL1190711 | — | IC50 | = | 1438.9 | nM | 5.84 |
| CHEMBL197603 | — | IC50 | = | 1577.14 | nM | 5.80 |
| CHEMBL64925 | MG-132 | IC50 | = | 1858.97 | nM | 5.73 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 2162.07 | nM | 5.67 |
| CHEMBL515416 | — | IC50 | = | 2329.07 | nM | 5.63 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 3411.59 | nM | 5.47 |
| CHEMBL401930 | — | IC50 | = | 3447.76 | nM | 5.46 |
| CHEMBL535 | SUNITINIB | IC50 | = | 3541.71 | nM | 5.45 |
| CHEMBL2144069 | — | IC50 | = | 5088.42 | nM | 5.29 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 5201.19 | nM | 5.28 |
| CHEMBL213100 | — | IC50 | = | 5962.1 | nM | 5.22 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 7270.67 | nM | 5.14 |
| CHEMBL1673039 | — | IC50 | = | 7864.41 | nM | 5.10 |
| CHEMBL221137 | EMBELIN | IC50 | = | 8674.34 | nM | 5.06 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 10496.92 | nM | 4.98 |
| CHEMBL135561 | — | IC50 | = | 10537.01 | nM | 4.98 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 12956.74 | nM | 4.89 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 13912.09 | nM | 4.86 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 14555.78 | nM | 4.84 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 16193.16 | nM | 4.79 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 16921.11 | nM | 4.77 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 18523.55 | nM | 4.73 |
| CHEMBL509032 | TAE-684 | IC50 | = | 19130.35 | nM | 4.72 |