Assay Detail
Functional
CHEMBL2363608
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SANGER: Inhibition of human RPMI-7951 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-7951 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.72 | 10.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 10.27 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.35 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.98 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.78 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.40 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.32 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.20 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 8.14 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.05 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.71 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.44 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.41 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.99 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.89 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.81 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.78 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.64 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.51 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.50 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.47 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.29 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.21 |
| CHEMBL585951 | — | — | 1 | 6.14 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.13 |
| CHEMBL3349342 | — | — | 1 | 6.12 |
| CHEMBL217354 | — | — | 1 | 6.05 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.91 |
| CHEMBL259181 | — | — | 1 | 5.85 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.71 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.05413 | nM | 10.27 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.448 | nM | 9.35 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.049 | nM | 8.98 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 1.658 | nM | 8.78 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 3.976 | nM | 8.40 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 4.753 | nM | 8.32 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 6.314 | nM | 8.20 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 7.175 | nM | 8.14 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 8.815 | nM | 8.05 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 19.28 | nM | 7.71 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 36.57 | nM | 7.44 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 38.97 | nM | 7.41 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 102.04 | nM | 6.99 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 130.14 | nM | 6.89 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 156.09 | nM | 6.81 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 167.55 | nM | 6.78 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 230.56 | nM | 6.64 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 309.87 | nM | 6.51 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 318.07 | nM | 6.50 |
| CHEMBL803 | CYTARABINE | IC50 | = | 339.52 | nM | 6.47 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 509.57 | nM | 6.29 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 611.23 | nM | 6.21 |
| CHEMBL585951 | — | IC50 | = | 720.51 | nM | 6.14 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 735.33 | nM | 6.13 |
| CHEMBL3349342 | — | IC50 | = | 761.19 | nM | 6.12 |
| CHEMBL217354 | — | IC50 | = | 888.31 | nM | 6.05 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 1244.43 | nM | 5.91 |
| CHEMBL259181 | — | IC50 | = | 1410.37 | nM | 5.85 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1952.97 | nM | 5.71 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2285.84 | nM | 5.64 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 2701.93 | nM | 5.57 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 2756.94 | nM | 5.56 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 3075.9 | nM | 5.51 |
| CHEMBL577784 | BX-795 | IC50 | = | 3185.21 | nM | 5.50 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 3201.37 | nM | 5.50 |
| CHEMBL573107 | — | IC50 | = | 3397.3 | nM | 5.47 |
| CHEMBL1190711 | — | IC50 | = | 3483.17 | nM | 5.46 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3747.23 | nM | 5.43 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 4063.44 | nM | 5.39 |
| CHEMBL105442 | CI-1040 | IC50 | = | 4255.89 | nM | 5.37 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 4224.13 | nM | 5.37 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 4570.02 | nM | 5.34 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 5802.83 | nM | 5.24 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 6640.03 | nM | 5.18 |
| CHEMBL202721 | — | IC50 | = | 7350.77 | nM | 5.13 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 8841.57 | nM | 5.05 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 8885.15 | nM | 5.05 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 9252.01 | nM | 5.03 |
| CHEMBL102714 | SB-216763 | IC50 | = | 11786.42 | nM | 4.93 |
| CHEMBL939 | GEFITINIB | IC50 | = | 11634.84 | nM | 4.93 |