Assay Detail
Functional
CHEMBL2363609
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SANGER: Inhibition of human RPMI-8226 cell growth in a cell viability assay.
129
Total Activities
128
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 129 | 5.73 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 8.92 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.63 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.54 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 8.38 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.30 |
| CHEMBL1256459 | TORIN1 | — | 1 | 8.19 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.17 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.96 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.83 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.79 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.77 |
| CHEMBL514499 | GW843682X | — | 1 | 7.55 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.53 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.47 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.34 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.00 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.93 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.92 |
| CHEMBL300389 | — | — | 1 | 6.89 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.76 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.67 |
| CHEMBL512504 | — | — | 1 | 6.61 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.54 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.50 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.48 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.41 |
| CHEMBL64925 | MG-132 | — | 2 | 6.37 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 6.34 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.33 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413 | SIROLIMUS | IC50 | = | 1.191 | nM | 8.92 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 2.346 | nM | 8.63 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 2.852 | nM | 8.54 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 4.148 | nM | 8.38 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 4.97 | nM | 8.30 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 6.51 | nM | 8.19 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 6.712 | nM | 8.17 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 11.02 | nM | 7.96 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 14.86 | nM | 7.83 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 16.02 | nM | 7.79 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 17.03 | nM | 7.77 |
| CHEMBL514499 | GW843682X | IC50 | = | 28.13 | nM | 7.55 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 29.49 | nM | 7.53 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 33.82 | nM | 7.47 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 45.99 | nM | 7.34 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 101.2 | nM | 7.00 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 117.19 | nM | 6.93 |
| CHEMBL513909 | BI-2536 | IC50 | = | 120.52 | nM | 6.92 |
| CHEMBL300389 | — | IC50 | = | 128.7 | nM | 6.89 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 174.64 | nM | 6.76 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 213.37 | nM | 6.67 |
| CHEMBL512504 | — | IC50 | = | 245.96 | nM | 6.61 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 285.89 | nM | 6.54 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 316.41 | nM | 6.50 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 328.11 | nM | 6.48 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 386.21 | nM | 6.41 |
| CHEMBL64925 | MG-132 | IC50 | = | 423.1 | nM | 6.37 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 456.52 | nM | 6.34 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 471.88 | nM | 6.33 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 526.86 | nM | 6.28 |
| CHEMBL509032 | TAE-684 | IC50 | = | 635.26 | nM | 6.20 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 663.23 | nM | 6.18 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 678.18 | nM | 6.17 |
| CHEMBL379300 | A-443654 | IC50 | = | 670.14 | nM | 6.17 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 827.14 | nM | 6.08 |
| CHEMBL38 | TRETINOIN | IC50 | = | 993.34 | nM | 6.00 |
| CHEMBL585951 | — | IC50 | = | 1034.45 | nM | 5.99 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1238.47 | nM | 5.91 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1282.89 | nM | 5.89 |
| CHEMBL2144069 | — | IC50 | = | 2466.47 | nM | 5.61 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 2629.53 | nM | 5.58 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 2731.64 | nM | 5.56 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 3143.78 | nM | 5.50 |
| CHEMBL189584 | PD-173074 | IC50 | = | 3234.47 | nM | 5.49 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 3626.16 | nM | 5.44 |
| CHEMBL1090090 | VX-702 | IC50 | = | 3823.76 | nM | 5.42 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 4116.31 | nM | 5.38 |
| CHEMBL3349342 | — | IC50 | = | 4510.42 | nM | 5.35 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 5054.61 | nM | 5.30 |