Assay Detail
Functional
CHEMBL2363625
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SANGER: Inhibition of human SCC-3 cell growth in a cell viability assay.
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SCC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 6.05 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509032 | TAE-684 | — | 1 | 10.22 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.62 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 8.07 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.92 |
| CHEMBL300389 | — | — | 1 | 7.42 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.38 |
| CHEMBL514499 | GW843682X | — | 1 | 7.31 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 7.21 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.17 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.05 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 6.96 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.89 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 6.45 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.35 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.29 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.29 |
| CHEMBL585951 | — | — | 1 | 6.24 |
| CHEMBL379300 | A-443654 | — | 1 | 6.21 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.00 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 5.99 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.92 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 5.90 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 5.76 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 5.74 |
| CHEMBL512504 | — | — | 1 | 5.69 |
| CHEMBL64925 | MG-132 | — | 2 | 5.61 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.55 |
| CHEMBL4298697 | — | — | 1 | 5.55 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.49 |
| CHEMBL515416 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509032 | TAE-684 | IC50 | = | 0.06029 | nM | 10.22 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 2.371 | nM | 8.62 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 8.519 | nM | 8.07 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 12.04 | nM | 7.92 |
| CHEMBL300389 | — | IC50 | = | 37.78 | nM | 7.42 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 41.64 | nM | 7.38 |
| CHEMBL514499 | GW843682X | IC50 | = | 48.68 | nM | 7.31 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 67.28 | nM | 7.17 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 89.64 | nM | 7.05 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 110.46 | nM | 6.96 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 128.51 | nM | 6.89 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 356.76 | nM | 6.45 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 445.79 | nM | 6.35 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 513.28 | nM | 6.29 |
| CHEMBL513909 | BI-2536 | IC50 | = | 518.73 | nM | 6.29 |
| CHEMBL585951 | — | IC50 | = | 582.1 | nM | 6.24 |
| CHEMBL379300 | A-443654 | IC50 | = | 620.41 | nM | 6.21 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1003.43 | nM | 6.00 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 1034.14 | nM | 5.99 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1210.17 | nM | 5.92 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1264.93 | nM | 5.90 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 1753.1 | nM | 5.76 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 1841.34 | nM | 5.74 |
| CHEMBL512504 | — | IC50 | = | 2043.11 | nM | 5.69 |
| CHEMBL64925 | MG-132 | IC50 | = | 2479.55 | nM | 5.61 |
| CHEMBL535 | SUNITINIB | IC50 | = | 2828.91 | nM | 5.55 |
| CHEMBL4298697 | — | IC50 | = | 2799.69 | nM | 5.55 |
| CHEMBL64925 | MG-132 | IC50 | = | 3108.48 | nM | 5.51 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 3206.06 | nM | 5.49 |
| CHEMBL515416 | — | IC50 | = | 4258.22 | nM | 5.37 |
| CHEMBL1190711 | — | IC50 | = | 7500.03 | nM | 5.12 |
| CHEMBL1673039 | — | IC50 | = | 8863.14 | nM | 5.05 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 10567.89 | nM | 4.98 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 14295.59 | nM | 4.84 |
| CHEMBL180127 | SALUBRINAL | IC50 | = | 22545.4 | nM | 4.65 |
| CHEMBL472940 | — | IC50 | = | 40274.16 | nM | 4.39 |
| CHEMBL1242367 | — | IC50 | = | 53403.81 | nM | 4.27 |
| CHEMBL401930 | — | IC50 | = | 54608.14 | nM | 4.26 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 67071.62 | nM | 4.17 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 77580.65 | nM | 4.11 |
| CHEMBL197603 | — | IC50 | = | 98505.46 | nM | 4.01 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 134842.31 | nM | - |
| CHEMBL221137 | EMBELIN | IC50 | = | 1370841.41 | nM | - |
| CHEMBL258844 | — | IC50 | = | 605700.72 | nM | - |
| CHEMBL191384 | — | IC50 | = | 781500.66 | nM | - |
| CHEMBL2363137 | — | IC50 | = | 250375.8 | nM | - |
| CHEMBL135561 | — | IC50 | = | 266059.24 | nM | - |
| CHEMBL591429 | PAC-1 | IC50 | = | 273234.12 | nM | - |
| CHEMBL558642 | GSK-650394 | IC50 | = | 157002.07 | nM | - |